Evidence map›Paper›PMID 30737416›Full record

ArticleScientific reports2019

Automated Tracking of Biopolymer Growth and Network Deformation with TSOAX.

Ting Xu, Christos Langouras, Maral Adeli Koudehi, Bart E Vos, Ning Wang, Gijsje H Koenderink, Xiaolei Huang, Dimitrios Vavylonis

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Kinesin-Induced Buckling Reveals the Limits of Microtubule Self-Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Automatic extraction of actin networks in plants.PLoS computational biology · 2023
    Article
  8. Article
  9. Tracing and tracking filamentous structures across scales: A systematic review.Computational and structural biotechnology journal · 2023
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ting XuDepartment of Computer Science and Engineering, Lehigh University, Bethlehem, PA, 18015, USA.
Christos LangourasDepartment of Physics, Lehigh University, Bethlehem, PA, 18015, USA.
Maral Adeli KoudehiDepartment of Physics, Lehigh University, Bethlehem, PA, 18015, USA.
Bart E VosAMOLF, Living Matter Department, 1098 XG, Amsterdam, The Netherlands.
Ning WangDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, 43210, USA.
Gijsje H KoenderinkAMOLF, Living Matter Department, 1098 XG, Amsterdam, The Netherlands.
Xiaolei HuangDepartment of Computer Science and Engineering, Lehigh University, Bethlehem, PA, 18015, USA. suh972@ist.psu.edu.
Dimitrios VavylonisDepartment of Physics, Lehigh University, Bethlehem, PA, 18015, USA. vavylonis@lehigh.edu.
Lehigh University · USInstitute for Atomic and Molecular Physics · NLHoward Hughes Medical Institute · US

Funding

Modeling and analysis of actin filament organization in yeastR01GM098430 · NIGMS · LEHIGH UNIVERSITY · PI VAVYLONIS, DIMITRIOS · 2012 to 2016
$1.3M
Theoretical and experimental studies of distributed actin turnoverR01GM114201 · NIGMS · LEHIGH UNIVERSITY · PI VAVYLONIS, DIMITRIOS · 2016 to 2019
$1.1M
NIGMS NIH HHS R01 GM098430NIGMS NIH HHS R01 GM114201U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM098430
6 · The paper itself

Abstract

Studies of how individual semi-flexible biopolymers and their network assemblies change over time reveal dynamical and mechanical properties important to the understanding of their function in tissues and living cells. Automatic tracking of biopolymer networks from fluorescence microscopy time-lapse sequences facilitates such quantitative studies. We present an open source software tool that combines a global and local correspondence algorithm to track biopolymer networks in 2D and 3D, using stretching open active contours. We demonstrate its application in fully automated tracking of elongating and intersecting actin filaments, detection of loop formation and constriction of tilted contractile rings in live cells, and tracking of network deformation under shear deformation.

Indexed as

AlgorithmsAutomationBiopolymersFibrinogenHumansMicroscopy, FluorescenceSoftwareTime-Lapse ImagingBiopolymersFibrinogen

Identifiers

PMID30737416
PMCPMC6368602
OpenAlexW2803043859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.