ArticleScientific reports2019
Alkali treated antioxidative crude polysaccharide from Russula alatoreticula potentiates murine macrophages by tunning TLR/NF-κB pathway.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Mechanisms of action of fungal polysaccharides and their therapeutic effect.European journal of clinical nutrition · 2025Review
- Unveiling the Bioactive Compounds and Therapeutic Potential ofJournal of fungi (Basel, Switzerland) · 2025Review
- Polysaccharides fromFrontiers in nutrition · 2024Review
- Antioxidation and immune-stimulatory actions of cold alkali extracted polysaccharide fraction from3 Biotech · 2022Article
- Understanding immune-modulatory efficacy in vitro.Chemico-biological interactions · 2022Review
- Extracellular Vesicle/Macrophage Axis: Potential Targets for Inflammatory Disease Intervention.Frontiers in immunology · 2022Review
- Exploration of nutritional, antioxidative, antibacterial and anticancer status ofJournal of food science and technology · 2021Article
- Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy.Frontiers in pharmacology · 2021Review
- Article
- Immunomodulatory Effects ofMolecules (Basel, Switzerland) · 2020Article
- Extract Methods, Molecular Characteristics, and Bioactivities of Polysaccharide from Alfalfa (Nutrients · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our previous research, Russula alatoreticula was demonstrated as a novel species, ethnic myco-food and reservoir of hot water extractable polysaccharides. However, residue after the hydrothermal process still offer plenty of medicinal carbohydrates that could easily be extracted by using alkali solvent. Thus, the present work was attempted to prepare crude polysaccharide using remainder of the conventional method and subsequently a β-glucan enriched fraction, RualaCap, was isolated. The bio-polymers displayed pronounced therapeutic efficacy as evident by radical scavenging, chelating ability, reducing power and total antioxidant capacity. In addition, strong immune-enhancing potential was also observed indicated by augmentation in macrophage viability, phagocytic uptake, nitric oxide (NO) production and reactive oxygen species (ROS) synthesis. Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-κB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, Iκ-Bα, interferon (IFN)-γ and interleukin (IL)-10 genes explaining mode of action. Taken together, our results signify possibility of RualaCap as a potent nutraceutical agent and enhance importance of R. alatoreticula especially in the field of innate immune stimulation.
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