ArticleNature communications2019
Conformations and cryo-force spectroscopy of spray-deposited single-strand DNA on gold.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Vision of Life's Code: Molecular Probe Nanoarchitectonics for Deep RNA/DNA Illumination.ACS nano · 2026Review
- Clean Electrospray Deposition of Porphyrin Molecules and Polyethylene Glycol Chains onto a Au(100) Surface.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026Article
- Laterally π-Extended Polyhelicenes.Journal of the American Chemical Society · 2025Article
- Probing Molecular Properties at Atomic Length Scale Using Charge-State Control.Chemical reviews · 2025Review
- On-Surface Synthesis and Cryogenic Exfoliation of Sterically Frustrated Atropisomers.ACS nano · 2025Article
- Selection of Plastic-Binding DNA Aptamers for Microplastics Detection.Angewandte Chemie (International ed. in English) · 2024Article
- Scanning Probe Microscopy Characterization of Biomolecules enabled by Mass-Selective, Soft-landing Electrospray Ion Beam Deposition.Chemphyschem : a European journal of chemical physics and physical chemistry · 2024Article
- Article
- Molecular sensitised probe for amino acid recognition within peptide sequences.Nature communications · 2023Article
- Dinuclear complex-induced DNA melting.Journal of nanobiotechnology · 2023Article
- Visualization and identification of single meteoritic organic molecules by atomic force microscopy.Meteoritics & planetary science · 2022Article
- Nanometer-Scale Force Profiles of Short Single- and Double-Stranded DNA Molecules on a Gold Surface Measured Using a Surface Forces Apparatus.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Predicting Finite-Bias Tunneling Current Properties from Zero-Bias Features: The Frontier Orbital Bias Dependence at an Exemplar Case of DNA Nucleotides in a Nanogap.Nanomaterials (Basel, Switzerland) · 2021Article
- Influence of electrospray deposition on CBeilstein journal of nanotechnology · 2021Article
- Structure-mechanics statistical learning unravels the linkage between local rigidity and global flexibility in nucleic acids.Chemical science · 2020Article
- Automated structure discovery in atomic force microscopy.Science advances · 2020Article
- Giant thermal expansion of a two-dimensional supramolecular network triggered by alkyl chain motion.Communications materials · 2020Article
- Tuning Structure and Dynamics of Blue Copper Azurin Junctions via Single Amino-Acid Mutations.Biomolecules · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryo-electron microscopy can determine the structure of biological matter in vitrified liquids. However, structure alone is insufficient to understand the function of native and engineered biomolecules. So far, their mechanical properties have mainly been probed at room temperature using tens of pico-newton forces with a resolution limited by thermal fluctuations. Here we combine force spectroscopy and computer simulations in cryogenic conditions to quantify adhesion and intra-molecular properties of spray-deposited single-strand DNA oligomers on Au(111). Sub-nanometer resolution images reveal folding conformations confirmed by simulations. Lifting shows a decay of the measured stiffness with sharp dips every 0.2-0.3 nm associated with the sequential peeling and detachment of single nucleotides. A stiffness of 30-35 N m
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.