Evidence map›Paper›PMID 30737360›Full record

ArticleAging2019

MicroRNA-141 suppresses growth and metastatic potential of head and neck squamous cell carcinoma.

Zhiguo Zhao, Dan Gao, Tie Ma, Liping Zhang

Open access · greenAbstract read
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhiguo ZhaoDepartment of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University, Shenyang, P.R.China.
Dan GaoDepartment of Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang, P.R.China.
Tie MaDepartment of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University, Shenyang, P.R.China.
Liping ZhangDepartment of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University, Shenyang, P.R.China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epidermal growth factor receptor (EGFR) were enhanced in tissues with low miR-141 expression but were reduced by miR-141 overexpression, and there was a significant negative correlation between EGFR and miR-141 levels in HNSCC tissues (

Indexed as

AdultAnimalsApoptosisCarcinoma, Squamous CellCase-Control StudiesCell Line, TumorErbB ReceptorsFemaleHead and Neck NeoplasmsHumansMaleMice, Inbred BALB CMicroRNAsNeoplasm MetastasisEGFR protein, humanErbB ReceptorsMicroRNAsMIRN141 microRNA, humanEGFRgrowthHNSCCmetastasismiR-141

Identifiers

PMID30737360
PMCPMC6382419
OpenAlexW2914301546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.