Evidence map›Paper›PMID 30737355›Full record

ArticleScience immunology2019

Diet modulates colonic T cell responses by regulating the expression of a

Marta M Wegorzewska, Robert W P Glowacki, Samantha A Hsieh, David L Donermeyer, Christina A Hickey, Stephen C Horvath, Eric C Martens, Thaddeus S Stappenbeck, Paul M Allen

Open access · bronzeAbstract read
In one paragraph

Article in Science immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 111 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. A conserved peptidase governs glucose homeostasis inbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Gene regulation inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Genomic specificity of anti-mouse TCR mAbs determined by single-cell RNAseq.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. Designing live bacterial therapeutics for cancer.Advanced drug delivery reviews · 2025
    Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marta M WegorzewskaDepartment of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA.ORCID 0000-0002-9662-4963
Robert W P GlowackiDepartment of Microbiology and Immunology, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA.
Samantha A HsiehDepartment of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA.ORCID 0000-0002-1846-2583
David L DonermeyerDepartment of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA.ORCID 0000-0002-3706-1611
Christina A HickeyDepartment of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA.ORCID 0000-0001-6541-0148
Stephen C HorvathDepartment of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA.ORCID 0000-0001-5324-1666
Eric C MartensDepartment of Microbiology and Immunology, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA. pallen@wustl.edu stappeb@wustl.edu emartens@umich.edu.ORCID 0000-0001-6681-2990
Thaddeus S StappenbeckDepartment of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA. pallen@wustl.edu stappeb@wustl.edu emartens@umich.edu.ORCID 0000-0002-6023-3901
Paul M AllenDepartment of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA. pallen@wustl.edu stappeb@wustl.edu emartens@umich.edu.
Washington University in St. Louis · USUniversity of Michigan · US

Funding

TRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8M
DEFINING HOST-MICROBIAL INTERACTIONS THAT TRIGGER INFLAMMATORY BOWEL DISEASER01DK097079 · NIDDK · WASHINGTON UNIVERSITY · PI ALLEN, PAUL M, STAPPENBECK, THADDEUS S · 2013 to 2016
$1.8M
Initiation of symbiont-driven inflammatory bowel diseases by genetic mutations in T cells and antigen-presenting cellsF30DK114950 · NIDDK · WASHINGTON UNIVERSITY · PI BAI, SAMANTHA HSIEH · 2017 to 2019
$111k
NIAID NIH HHS T32 AI007163NIDDK NIH HHS F30 DK114950NIDDK NIH HHS R01 DK097079
6 · The paper itself

Abstract

T cell responses to symbionts in the intestine drive tolerance or inflammation depending on the genetic background of the host. These symbionts in the gut sense the available nutrients and adapt their metabolic programs to use these nutrients efficiently. Here, we ask whether diet can alter the expression of a bacterial antigen to modulate adaptive immune responses. We generated a CD4

Indexed as

DietAdoptive TransferAnimalsAntigens, BacterialBacterial ProteinsBacteroides thetaiotaomicronCell DifferentiationColitisColonCulture MediaEscherichia coliGlucoseHybridomasMiceMice, Inbred C57BLMice, TransgenicAntigens, BacterialBacterial ProteinsCulture MediaGlucoseNutrientsReceptors, Antigen, T-Cell

Identifiers

PMID30737355
PMCPMC6550999
OpenAlexW2914927239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.