Evidence map›Paper›PMID 30737349›Full record

ArticleApplied and environmental microbiology2019

Detection of Natural Products and Their Producers in Ocean Sediments.

Robert N Tuttle, Alyssa M Demko, Nastassia V Patin, Clifford A Kapono, Mohamed S Donia, Pieter Dorrestein, Paul R Jensen

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  5. ACS central science · 2023
    Article
  6. The Bacterial GJournal of chemical ecology · 2023
    Article
  7. Article
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  10. Habitat-adapted heterologous symbiontFrontiers in plant science · 2022
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Robert N TuttleCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
Alyssa M DemkoCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
Nastassia V PatinCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-8522-7682
Clifford A KaponoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.
Mohamed S DoniaDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Pieter DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.
Paul R JensenCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA pjensen@ucsd.edu.
Scripps Institution of Oceanography · USUniversity of California San Diego · USPrinceton University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thousands of natural products have been identified from cultured microorganisms, yet evidence of their production in the environment has proven elusive. Technological advances in mass spectrometry, combined with public databases, now make it possible to address this disparity by detecting compounds directly from environmental samples. Here, we used adsorbent resins, tandem mass spectrometry, and next-generation sequencing to assess the metabolome of marine sediments and its relationship to bacterial community structure. We identified natural products previously reported from cultured bacteria, providing evidence they are produced

Indexed as

Oceans and SeasBacteriaBiological ProductsDrug DiscoveryGeologic SedimentsHigh-Throughput Nucleotide SequencingMetabolomeMetabolomicsMetagenomeMicrobiotaMicromonosporaceaeMultigene FamilySeawaterBiological Productsmetabolomicsmetagenomicsmicrobiomenatural productsSalinispora

Identifiers

PMID30737349
PMCPMC6450032
OpenAlexW2913430374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.