ArticleNeurology2019
Genetic basis of motoric cognitive risk syndrome in the Health and Retirement Study.
Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Mechanisms of motoric cognitive risk-Hypotheses based on a systematic review and meta-analysis of longitudinal cohort studies of older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Pooled it
- Association of Long-Term Trajectories in Obesity Indices With Neuroimaging Metrics and Cognition: A Population-Based Study.Diabetes, obesity & metabolism · 2026Article
- Sex-specific brain atrophy patterns associated with the motoric cognitive risk syndrome.Journal of Alzheimer's disease : JAD · 2025Article
- From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome.Aging and disease · 2025Review
- Pulmonary function and motoric cognitive risk syndrome in older adults.Scientific reports · 2025Article
- Multimorbidity patterns and cognitive frailty in adults aged over 50 years: China perspective.Frontiers in public health · 2025Article
- Association between pain interference and motoric cognitive risk syndrome in older adults: a population-based cohort study.BMC geriatrics · 2024Article
- Subjective Cognitive Decline and Genetic Propensity for Dementia beyond Apolipoprotein εCurrent issues in molecular biology · 2024Review
- Presymptomatic Profiles of Cognitive Impairment with Prior Mobility Impairment.Journal of the American Medical Directors Association · 2024Article
- Biological Age Acceleration and Motoric Cognitive Risk Syndrome.Annals of neurology · 2023Article
- Dual cognitive and mobility impairments and future dementia - Setting a research agenda.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Facets of conscientiousness and motoric cognitive risk syndrome.Journal of psychiatric research · 2022Article
- Risk factors, neuroimaging correlates and prognosis of the motoric cognitive risk syndrome: A population-based comparison with mild cognitive impairment.European journal of neurology · 2022Article
- Inflammatory biomarkers and motoric cognitive risk syndrome: Multicohort survey.Cerebral circulation - cognition and behavior · 2022Article
- Slow Gait, Subjective Cognitive Decline and Motoric Cognitive RISK Syndrome: Prevalence and Associated Factors in Community Dwelling Older Adults.The journal of nutrition, health & aging · 2021Article
- Cortical Thickness, Volume, and Surface Area in the Motoric Cognitive Risk Syndrome.Journal of Alzheimer's disease : JAD · 2021Article
- Motoric Cognitive Risk Syndrome: Symptoms, Pathology, Diagnosis, and Recovery.Frontiers in aging neuroscience · 2021Review
- Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young.Environmental research · 2020Article
- Non-memory subjective cognitive concerns predict incident motoric cognitive risk syndrome.European journal of neurology · 2020Article
- Personality and Motoric Cognitive Risk Syndrome.Journal of the American Geriatrics Society · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine polygenic inheritance of motoric cognitive risk syndrome (MCR), a predementia syndrome characterized by the presence of subjective cognitive complaints and slow gait.
methodsWe analyzed 4,915 individuals, age 65 years and above, with European ancestry (mean age 75.0 ± 6.8 years, 56.6% women) in the Health and Retirement Study. Polygenic scores (PGS) were calculated as weighted sums of the effect of single nucleotide polymorphisms, with effect sizes derived from genome-wide association studies. The association between PGSs of 9 phenotypes (general cognition, body mass index [BMI], mean arterial pressure, education, Alzheimer disease [AD], neuroticism, well-being, waist circumference, and depressive symptoms) and MCR as well as its key components (cognitive complaints and slow gait) were examined by logistic regression, adjusting for age, sex, education, and genetic ancestry, and reported as odds ratios (ORs) with 95% confidence intervals (CIs).
resultsThere were 260 prevalent MCR cases, 529 with slow gait, and 1,928 with subjective cognitive complaints. Higher PGSs for BMI (OR 1.22, 95% CI 1.07-1.39) and waist circumference (OR 1.23, 95% CI 1.07-1.40) were associated with MCR, and PGS of AD showed a suggestive association (OR 1.16, 95% CI 1.02-1.32). Higher PGS for neuroticism (OR 1.10, 95% CI 1.03-1.18) was associated with cognitive complaints, whereas higher well-being PGS (OR 0.92, 95% CI 0.87-0.98) was protective. PGS for BMI (OR 1.16, 95% CI 1.06-1.28), waist circumference (OR 1.19, 95% CI 1.08-1.31), and AD (OR 1.13, 95% CI 1.03-1.24) was associated with slow gait.
conclusionObesity-related genetic traits increase risk of MCR syndrome; further investigation is required to identify potential therapeutic targets.
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