Evidence map›Paper›PMID 30737317›Full record

ArticleThe Journal of biological chemistry2019

A seven-step plan for becoming a moderately rich and famous biochemist.

William L Smith

Open access · hybridAbstract readHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Allosteric regulation of prostaglandin endoperoxide HThe Journal of biological chemistry · 2025
    Review
  2. Article
  3. Essentiality ofThe Journal of biological chemistry · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

William L SmithFrom the Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606 smithww@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Pilot Study: POPULATION PHARMACOLOGYU54HL117798 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2016
$18.5M
Translational Research in GI CancerP50CA130810 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, DEAN E. · 2010 to 2016
$11.8M
Catalysis by Prostaglandin Endoperoxide H SynthasesR01GM068848 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, WILLIAM L · 2003 to 2014
$5.6M
NCI NIH HHS P50 CA130810NHLBI NIH HHS U54 HL117798NIGMS NIH HHS R01 GM068848
6 · The paper itself

Abstract

Omega-6 polyunsaturated fatty acids were identified as essential nutrients in 1930. Their essentiality is largely due to their function as prostaglandin (PG) precursors. I spent most of my career in biochemistry determining how PG biosynthesis is regulated. PGs are lipid mediators formed in response to certain circulating hormones and cytokines. PGs act near their sites of synthesis to signal neighboring cells to coordinate their responses (

Indexed as

Anti-Inflammatory Agents, Non-SteroidalCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsBiochemistryHistory, 20th CenturyHistory, 21st CenturyHumansProstaglandin H2Anti-Inflammatory Agents, Non-SteroidalCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsProstaglandin H2PTGS1 protein, humanPTGS2 protein, humanarachidonic acid (AA) (ARA)aspirincelecoxibCOX-2cyclooxygenase (COX)eicosanoidhalf-siteslipid mediatornaproxenNSAIDomega-3 fatty acidprostaglandin

Identifiers

PMID30737317
PMCPMC6369280
OpenAlexW2913936303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.