Evidence map›Paper›PMID 30737312›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis.

Rianne R Campbell, Racquel D Domingo, Amy R Williams, Melissa G Wroten, Hadley A McGregor, Ryan S Waltermire, Daniel I Greentree, Scott P Goulding, Andrew B Thompson, Kaziya M Lee and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Review
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  7. Review
  8. Review
  9. Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping.International journal of molecular sciences · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Hnrnph1 is a novel regulator of alcohol reward.Drug and alcohol dependence · 2021
    Article
  14. Article
  15. Article
  16. mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  17. Adolescent alcohol exposure produces sex differences in negative affect-like behavior and group I mGluR BNST plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Rianne R CampbellDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Racquel D DomingoDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Amy R WilliamsDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Melissa G WrotenDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Hadley A McGregorDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Ryan S WaltermireDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Daniel I GreentreeDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Scott P GouldingDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Andrew B ThompsonDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Kaziya M LeeDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Sema G QuadirDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
C Leonardo Jimenez ChavezDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Michal A CoelhoDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Adam T GouldDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Georg von JonquieresTranslational Neuroscience Facility, School of Medical Sciences, University of New South Wales, New South Wales 2052, Australia, and.
Matthias KlugmannTranslational Neuroscience Facility, School of Medical Sciences, University of New South Wales, New South Wales 2052, Australia, and.
Paul F WorleyDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Tod E KippinDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660.
Karen K SzumlinskiDepartment of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106-9660, karen.szumlinski@psych.ucsb.edu.
University of California, Santa Barbara · USNeuroscience Research Australia · AUJohns Hopkins University · US

Funding

Molecular regulation of CeA glutamate and binge drinkingR01AA016650 · NIAAA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SZUMLINSKI, KAREN KATHLEEN · 2010 to 2014
$1.7M
NIAAA NIH HHS R01 AA016650
6 · The paper itself

Abstract

The bed nucleus of the stria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses to stress, and glutamate transmission within this region has been implicated in the neurobiology of alcoholism. Herein, we used a combination of immunoblotting, neuropharmacological and transgenic procedures to investigate the role for metabotropic glutamate receptor 5 (mGlu5) signaling within the BNST in excessive drinking. We discovered that mGlu5 signaling in the BNST is linked to excessive alcohol consumption in a manner distinct from behavioral or neuropharmacological endophenotypes that have been previously implicated as triggers for heavy drinking. Our studies demonstrate that, in male mice, a history of chronic binge alcohol-drinking elevates BNST levels of the mGlu5-scaffolding protein Homer2 and activated extracellular signal-regulated kinase (ERK) in an adaptive response to limit alcohol consumption. Male and female transgenic mice expressing a point mutation of mGlu5 that cannot be phosphorylated by ERK exhibit excessive alcohol-drinking, despite greater behavioral signs of alcohol intoxication and reduced anxiety, and are insensitive to local manipulations of signaling in the BNST. These transgenic mice also show selective insensitivity to alcohol-aversion and increased novelty-seeking, which may be relevant to excessive drinking. Further, the insensitivity to alcohol-aversion exhibited by male mice can be mimicked by the local inhibition of ERK signaling within the BNST. Our findings elucidate a novel mGluR5-linked signaling state within BNST that plays a central and unanticipated role in excessive alcohol consumption.

Indexed as

Alcohol DrinkingAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPhosphorylationReceptor, Metabotropic Glutamate 5Septal NucleiGrm5 protein, mouseReceptor, Metabotropic Glutamate 5anxietybed nucleus of the stria terminalisbinge-drinkingextracellular signal-regulated kinaseHomer proteinmGlu5 receptor

Identifiers

PMID30737312
PMCPMC6445984
OpenAlexW2911518850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.