ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Rod Photoresponse Kinetics Limit Temporal Contrast Sensitivity in Mesopic Vision.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Reproducible magnetophosphene thresholds induced by transcranial alternating magnetic stimulation in humans: a replication study.Scientific reports · 2026Article
- Widespread and Convergent Evolution of Cone Monochromacy in Galeomorph Sharks.Molecular biology and evolution · 2025Article
- A Review of Cervidae Visual Ecology.Animals : an open access journal from MDPI · 2024Review
- Daylights with high melanopsin stimulation appear reddish in fovea and greenish in periphery.PloS one · 2023Article
- Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Phenotype Characterization of a Mice Genetic Model of Absolute Blindness.International journal of molecular sciences · 2022Article
- Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Effect of ambient lighting on frequency dependence in transcranial electrical stimulation-induced phosphenes.Scientific reports · 2022Article
- Differential impact of Kv8.2 loss on rod and cone signaling and degeneration.Human molecular genetics · 2022Article
- Rod Photoreceptors Signal Fast Changes in Daylight Levels Using a Cx36-Independent Retinal Pathway in Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian visual system operates over an extended range of ambient light levels by switching between rod and cone photoreceptors. Rod-driven vision is sluggish, highly sensitive, and operates in dim or scotopic lights, whereas cone-driven vision is brisk, less sensitive, and operates in bright or photopic lights. At intermediate or mesopic lights, vision transitions seamlessly from rod-driven to cone-driven, despite the profound differences in rod and cone response dynamics. The neural mechanisms underlying such a smooth handoff are not understood. Using an operant behavior assay, electrophysiological recordings, and mathematical modeling we examined the neural underpinnings of the mesopic visual transition in mice of either sex. We found that rods, but not cones, drive visual sensitivity to temporal light variations over much of the mesopic range. Surprisingly, speeding up rod photoresponse recovery kinetics in transgenic mice improved visual sensitivity to slow temporal variations, in the range where perceptual sensitivity is governed by Weber's law of sensation. In contrast, physiological processes acting downstream from phototransduction limit sensitivity to high frequencies and temporal resolution. We traced the paradoxical control of visual temporal sensitivity to rod photoresponses themselves. A scenario emerges where perceptual sensitivity is limited by: (1) the kinetics of neural processes acting downstream from phototransduction in scotopic lights, (2) rod response kinetics in mesopic lights, and (3) cone response kinetics as light levels rise into the photopic range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.