Evidence map›Paper›PMID 30737306›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety.

Anne S Berry, Robert L White, Daniella J Furman, Jenna R Naskolnakorn, Vyoma D Shah, Mark D'Esposito, William J Jagust

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. VTA-ACC dopaminergic circuit mediates trait anxiety-related observational learning of social avoidance in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  9. Article
  10. Article
  11. Dorsal raphe dopaminergic neurons target CaMKIITranslational psychiatry · 2024
    Article
  12. Article
  13. Mesocorticolimbic and Cardiometabolic Diseases-Two Faces of the Same Coin?International journal of molecular sciences · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The cerebellum and anxiety.Frontiers in cellular neuroscience · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anne S BerryLawrence Berkeley National Laboratory, Berkeley, California 94720, and anneberry@berkeley.edu.ORCID 0000-0002-5086-3643
Robert L WhiteHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California 94720.
Daniella J FurmanHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California 94720.
Jenna R NaskolnakornHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California 94720.
Vyoma D ShahLawrence Berkeley National Laboratory, Berkeley, California 94720, and.
Mark D'EspositoHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California 94720.ORCID 0000-0002-3462-006X
William J JagustLawrence Berkeley National Laboratory, Berkeley, California 94720, and.ORCID 0000-0002-4458-113X
University of California, Berkeley · USLawrence Berkeley National Laboratory · US

Funding

Aging Brain, Cognition, and DopamineR01AG044292 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2013 to 2017
$3.6M
Dopamine and Frontostriatal FunctionR01DA034685 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI D'ESPOSITO, MARK · 2013 to 2017
$3.4M
Age effects on memory and reward systems in decision makingK99AG058748 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BERRY, ANNE SHIVELY · 2018 to 2019
$250k
NIA NIH HHS K99 AG058748NIA NIH HHS R01 AG044292NIDA NIH HHS R01 DA034685
6 · The paper itself

Abstract

Trait anxiety has been associated with altered activity within corticolimbic pathways connecting the amygdala and rostral anterior cingulate cortex (rACC), which receive rich dopaminergic input. Though the popular culture uses the term "chemical imbalance" to describe the pathophysiology of psychiatric conditions such as anxiety disorders, we know little about how individual differences in human dopamine neurochemistry are related to variation in anxiety and activity within corticolimbic circuits. We addressed this issue by examining interindividual variability in dopamine release at rest using [

Indexed as

AdolescentAdultAnxietyDopamineDopamine AntagonistsFemaleGyrus CinguliHumansMagnetic Resonance ImagingMalePositron-Emission TomographyRacloprideReceptors, Dopamine D2Receptors, Dopamine D3Young AdultDopamineDopamine AntagonistsRacloprideReceptors, Dopamine D2Receptors, Dopamine D3amygdalaanterior cingulateanxietydopaminefMRIraclopride

Identifiers

PMID30737306
PMCPMC6445999
OpenAlexW2913343119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.