Evidence map›Paper›PMID 30737279›Full record

ArticleThe Journal of biological chemistry2019

A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart.

Markus Horsthemke, Lauryl M J Nutter, Anne C Bachg, Boris V Skryabin, Ulrike Honnert, Thomas Zobel, Sven Bogdan, Monika Stoll, Matthias D Seidl, Frank U Müller and 7 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Myosin 18Aα targets the guanine nucleotide exchange factor β-Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  5. Review
  6. Motor Proteins and Spermatogenesis.Advances in experimental medicine and biology · 2021
    Review
  7. Article
  8. Unconventional myosins muscle into myofibrils.The Journal of biological chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 5 countries.

Markus HorsthemkeFrom the Institut für Molekulare Zellbiologie.
Lauryl M J Nutterthe Centre for Phenogenomics, Hospital for Sick Children, Toronto, Ontario M5T 3H7, Canada.
Anne C BachgFrom the Institut für Molekulare Zellbiologie.
Boris V SkryabinDepartment of Medicine, Transgenic Animal and Genetic Engineering Models (TRAM).
Ulrike HonnertFrom the Institut für Molekulare Zellbiologie.
Thomas Zobelthe Center for Advanced Imaging, Heinrich Heine Universität Düsseldorf, 40225 Düsseldorf, Germany.
Sven Bogdanthe Institut für Physiologie und Pathophysiologie, Abteilung Molekulare Zellphysiologie, Philipps-Universität Marburg, 35037 Marburg, Germany.
Monika StollInstitut für Humangenetik, and.
Matthias D SeidlInstitut für Pharmakologie und Toxikologie, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany.
Frank U MüllerInstitut für Pharmakologie und Toxikologie, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany.
Ursula Ravensthe Institut für Experimentelle Kardiovaskuläre Medizin, Universitätsklinikum Freiburg, 79110 Freiburg, Germany.
Andreas Ungerthe Institut für Physiologie II, Westfälische Wilhelms-Universität Münster, Robert-Koch-Strasse 27b, 48149 Münster, Germany, and.
Wolfgang A Linkethe Institut für Physiologie II, Westfälische Wilhelms-Universität Münster, Robert-Koch-Strasse 27b, 48149 Münster, Germany, and.ORCID 0000-0003-0801-3773
Pim R R van Gorpthe Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.
Antoine A F de Vriesthe Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.ORCID 0000-0002-4787-7155
Martin BählerFrom the Institut für Molekulare Zellbiologie.
Peter J HanleyFrom the Institut für Molekulare Zellbiologie, hanley@uni-muenster.de.
University of Münster · DEInstitute of Molecular Biotechnology · ATLeiden University Medical Center · NLHeinrich Heine University Düsseldorf · DEHospital for Sick Children · CAPhilipps University of Marburg · DEUniversity Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whereas myosin 18B (Myo18B) is known to be a critical sarcomeric protein, the function of myosin 18A (Myo18A) is unclear, although it has been implicated in cell motility and Golgi shape. Here, we show that homozygous deletion (homozygous tm1a, tm1b, or tm1d alleles) of

Indexed as

AnimalsGene DeletionGenes, LethalGreen Fluorescent ProteinsHumansMiceMice, KnockoutMyocardiumMyosinsProtein IsoformsSarcomeresenhanced green fluorescent proteinGreen Fluorescent ProteinsMyo18a protein, mouseMyosinsProtein Isoformsgene knockoutheartmacrophagemolecular motormyosin

Identifiers

PMID30737279
PMCPMC6509511
OpenAlexW2914124231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.