Evidence map›Paper›PMID 30737213›Full record

ArticleCancer discovery2019

Variety Is the Spice of Life, but Maybe Not in Gastroesophageal Adenocarcinomas.

Samuel J Klempner, Daniel V T Catenacci

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cancer discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. The oncologist · 2019
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

  • Comment on
    2019
5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Samuel J KlempnerThe Angeles Clinic and Research Institute, Los Angeles, California. sklempner@theangelesclinic.org.ORCID 0000-0002-4062-0808
Daniel V T CatenacciDepartment of Medicine, Section of Hematology & Oncology, The University of Chicago Medical Center & Biological Sciences, Chicago, Illinois.
Cedars-Sinai Medical Center · USUniversity of Chicago Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sanchez-Vega and colleagues prospectively demonstrate that both intra- and intertumoral differential expression of the receptor tyrosine kinases HER2, EGFR, and MET dictate sensitivity to the pan-HER inhibitor afatinib in a phase II trial of trastuzumab-refractory

Indexed as

AdenocarcinomaAntineoplastic AgentsGastrointestinal NeoplasmsAfatinibErb-b2 Receptor Tyrosine KinasesErbB ReceptorsFemaleHumansTrastuzumabAfatinibAntineoplastic AgentsEGFR protein, humanERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesErbB ReceptorsTrastuzumab

Identifiers

PMID30737213
OpenAlexW2914874495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.