ArticleThe Lancet. Planetary health2019
Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort.
Article in The Lancet. Planetary health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- An ancestral molecular response to nanomaterial particulates.Nature nanotechnology · 2023Pooled it
- Exposure profiles of legacy and emerging per- and polyfluoroalkyl substances in follicular fluid and their impacts on assisted reproductive outcomes: A multicenter study in China.Eco-Environment & Health · 2026Article
- Update of the human early life exposome (HELIX) cohort: a European population-based exposome cohort-cohort profile.BMJ open · 2026Article
- Chemical exposome patterns in mothers and children across urbanisation levels in five European birth cohorts.Journal of exposure science & environmental epidemiology · 2026Article
- Predicting toxicity and bioactivity of the chemical exposome: a case study for the blood exposome database.Journal of cheminformatics · 2026Article
- Associations of metal mixtures in early pregnancy with lung function and asthma in mid-childhood in Project Viva.American journal of epidemiology · 2026Article
- Reforming schools into health promoting schools: perspective based on expert consensus from a European multistakeholder consultation.European journal of pediatrics · 2026Article
- Exposome studies can improve lung health.Nature · 2026Article
- Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood.Environmental research · 2025Article
- Association of prenatal exposure to phthalates with risks of asthma, wheeze, and allergic diseases during childhood: a systematic review and meta-analysis.Journal of environmental health science & engineering · 2025Article
- Predicting Toxicity and Bioactivity of the Chemical Exposome: A Case Study for the Blood Exposome Database.bioRxiv : the preprint server for biology · 2025Article
- Early-life exposure to a mixture of phenols and respiratory health in preschool children.The European respiratory journal · 2025Article
- Genomics and multiomics in the age of precision medicine.Pediatric research · 2025Review
- Article
- The need for a cancer exposome atlas: a scoping review.JNCI cancer spectrum · 2025Article
- Association between urinary exposures and the risk of chronic obstructive pulmonary disease in smokers: results from NHANES 2007-2016.Frontiers in public health · 2025Article
- Per and poly-fluoroalkyl substances and respiratory health in an Inuit community.Environmental health : a global access science source · 2024Article
- Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.Environmental health perspectives · 2024Article
- Associations of prenatal exposure to phthalates and their mixture with lung function in Mexican children.Journal of hazardous materials · 2024Article
- Machine learning-based health environmental-clinical risk scores in European children.Communications medicine · 2024Article
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Authors and funding
30 authors at 10 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children.
methodsIn this analysis, we used data from 1033 mother-child pairs from the European Human Early-Life Exposome (HELIX) cohort (consisting of six existing longitudinal birth cohorts in France, Greece, Lithuania, Norway, Spain, and the UK of children born between 2003 and 2009) for whom a valid spirometry test was recorded for the child. 85 prenatal and 125 postnatal exposures relating to outdoor, indoor, chemical, and lifestyle factors were assessed, and lung function was measured by spirometry in children at age 6-12 years. Two agnostic linear regression methods, a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering exposures independently, were applied to test the association with forced expiratory volume in 1 s percent predicted values (FEV
findingsIn the 1033 children (median age 8·1 years, IQR 6·5-9·0), mean FEV
interpretationOur systematic exposome approach identified several environmental exposures, mainly chemicals, that might be associated with lung function. Reducing exposure to these ubiquitous chemicals could help to prevent the development of chronic respiratory disease.
fundingEuropean Community's Seventh Framework Programme (HELIX project).
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