Evidence map›Paper›PMID 30736863›Full record

ArticleVeterinary research2019

Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro.

Anne Liljander, Flavio Sacchini, Michael H Stoffel, Elise Schieck, Nadine Stokar-Regenscheit, Fabien Labroussaa, Martin Heller, Jeremy Salt, Joachim Frey, Laurent Falquet and 2 more

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  8. Genome Engineering of the Fast-GrowingACS synthetic biology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Anne LiljanderInternational Livestock Research Institute, Box 30709, Nairobi, 00100, Kenya.
Flavio SacchiniInternational Livestock Research Institute, Box 30709, Nairobi, 00100, Kenya.
Michael H StoffelDivision of Veterinary Anatomy, Vetsuisse Faculty, University of Bern, Länggass-Str. 120, Postfach, 3001, Bern, Switzerland.
Elise SchieckInternational Livestock Research Institute, Box 30709, Nairobi, 00100, Kenya.
Nadine Stokar-RegenscheitInstitute of Animal Pathology (COMPATH), Vetsuisse Faculty, University of Bern, Länggass-Str. 122, Postfach, 3001, Bern, Switzerland.
Fabien LabroussaaInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Länggass-Str. 122, Postfach, 3001, Bern, Switzerland.
Martin HellerFriedrich-Loeffler-Institute-Federal Research Institute for Animal Health, Naumburger Str. 96a, 07743, Jena, Germany.
Jeremy SaltGALVmed, Doherty Building, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh, EH26 0PZ, Scotland, UK.
Joachim FreyInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Länggass-Str. 122, Postfach, 3001, Bern, Switzerland.
Laurent FalquetDivision of Biochemistry, Department of Biology, University of Fribourg and Swiss Institute of Bioinformatics, Chemin du Musée 18, 1700, Fribourg, Switzerland.
Danny GoovaertsGALVmed, Doherty Building, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh, EH26 0PZ, Scotland, UK.
Joerg JoresInternational Livestock Research Institute, Box 30709, Nairobi, 00100, Kenya. joerg.jores@vetsuisse.unibe.ch.ORCID http://orcid.org/0000-0003-3790-5746
University of Bern · CHGlobal Alliance for Livestock Veterinary Medicines · GBInternational Livestock Research Institute · KEFriedrich-Loeffler-Institut · DESIB Swiss Institute of Bioinformatics · CH

Funding

Bill and Melinda Gates Foundation (US) ILR-R38A0673 through GALVmedCGIAR Research Program on Livestock CRP 3.7UK Aid ILR-R38A0673 through GALVmed
6 · The paper itself

Abstract

Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae is a severe disease widespread in Africa and Asia. Limited knowledge is available on the pathogenesis of this organism, mainly due to the lack of a robust in vivo challenge model and the means to do site-directed mutagenesis. This work describes the establishment of a novel caprine challenge model for CCPP that resulted in 100% morbidity using a combination of repeated intranasal spray infection followed by a single transtracheal infection employing the recent Kenyan outbreak strain ILRI181. Diseased animals displayed CCPP-related pathology and the bacteria could subsequently be isolated from pleural exudates and lung tissues in concentrations of up to 10

Indexed as

Virus ReplicationAnimalsGoat DiseasesGoatsHydrogen PeroxideImmune SeraIn Vitro TechniquesMycoplasma capricolumPleuropneumonia, ContagiousSequence Analysis, DNAHydrogen PeroxideImmune Sera

Identifiers

PMID30736863
PMCPMC6368817
OpenAlexW2940909032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.