Evidence map›Paper›PMID 30736832›Full record

ArticleTrials2019

Physical Activity In Renal Disease (PAIRED) and the effect on hypertension: study protocol for a randomized controlled trial.

Stephanie Thompson, Natasha Wiebe, Gabor Gyenes, Rachelle Davies, Jeyasundar Radhakrishnan, Michelle Graham

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03551119 (Physical Activity in Renal Disease), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03551119 phase3terminatednot on this map

Physical Activity in Renal Disease (PAIRED): A Randomized Controlled Trial of the Effect on Hypertension

TypeinterventionalSponsorUniversity of AlbertaRan2018 to 2020Enrolled44ConditionsChronic Kidney DiseasesArmsExercise, Enhanced usual care
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephanie ThompsonDivision of Nephrology and Immunology, 11-112R CSB, 152 University Campus NW, University of Alberta, 11-112 Clinical Sciences Building, Edmonton, AB, T6G 2G3, Canada. th11@ualberta.ca.
Natasha WiebeDivision of Nephrology and Immunology, 11-112R CSB, 152 University Campus NW, University of Alberta, 11-112 Clinical Sciences Building, Edmonton, AB, T6G 2G3, Canada.
Gabor GyenesDepartment of Cardiology, Mackenzie Health Science Centre, 8440-112 Street, Edmonton, AB, T6G 2B7, Canada.
Rachelle DaviesDivision of Nephrology and Immunology, 11-112R CSB, 152 University Campus NW, University of Alberta, 11-112 Clinical Sciences Building, Edmonton, AB, T6G 2G3, Canada.
Jeyasundar RadhakrishnanInnovation Physical Therapy, 15823 97 Street NW #209, Edmonton, AB, T5X 0C7, Canada.
Michelle GrahamDepartment of Cardiology, Mackenzie Health Science Centre, 8440-112 Street, Edmonton, AB, T6G 2B7, Canada.

Funding

Canadian Institutes of Health Research 391467
6 · The paper itself

Abstract

backgroundThe prevalence of hypertension among people with chronic kidney disease is high with over 60% of people not attaining recommended targets despite taking multiple medications. Given the health and economic implications of hypertension, additional strategies are needed. Exercise is an effective strategy for reducing blood pressure in the general population; however, it is not known whether exercise would have a comparable benefit in people with moderate to advanced chronic kidney disease and hypertension.

methodsThis is a parallel-arm trial of adults with hypertension (systolic blood pressure greater than 130 mmHg) and an estimated glomerular filtration rate of 15-45 ml/min 1.73 m DISCUSSION: To our knowledge, this study is the first trial designed to provide a precise estimate of the effect of exercise on blood pressure in people with moderate to severe CKD and hypertension. The findings from this study should address a significant knowledge gap in hypertension management in CKD and inform the design of a larger study on the effect of exercise on CKD progression.

trial registrationClinicalTrials.gov, ID: NCT03551119 . Registered on 11 June 2018.

Indexed as

Blood PressureGlomerular Filtration RateAlbertaAntihypertensive AgentsExercise TherapyHumansHypertensionKidneyRandomized Controlled Trials as TopicRenal Insufficiency, ChronicSeverity of Illness IndexTime FactorsTreatment OutcomeAntihypertensive AgentsAmbulatory blood pressureBlood-pressureChronic kidney diseaseExerciseHypertensionRandomized trial

Identifiers

PMID30736832
PMCPMC6368686

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.