ReviewMicrobial cell factories2019
Engineering microbial consortia by division of labor.
Review in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
96 citing papers in PubMed.
- Advances in erythritol production through synthetic biology and systems metabolic engineering.Archives of microbiology · 2026Review
- A Proposed Cross-Feeding Model of Phenanthrene Degradation by Constructed Halophilic Consortium NOMA.Microorganisms · 2026Article
- Plant growth-promoting Pseudomonas strains modulate potato tuberization signalling and development.Journal of experimental botany · 2026Article
- Synthetic microbial communities derived from native niches enhance the high-temperature adaptability of Pinus yunnanensis seedlings.Environmental microbiome · 2026Article
- Bacterial degradation of aromatic ester pollutants in agro-ecosystems: implications for bioremediation.Applied microbiology and biotechnology · 2026Review
- A cooperative cobalamide biosynthesis guild in the endosphere of the edible aquatic plant Wolffia globosa Mankai.Environmental microbiome · 2026Article
- Active Chitosan Films Enriched with Yerba Mate Kombucha Infusion: Formulation and Characterization.International journal of molecular sciences · 2026Article
- Rethinking Microbial Chemical Ecology: Secondary Metabolites as Concentration-Dependent Signaling Hubs with Implications for Anti-Virulence Intervention.Microorganisms · 2026Review
- Engineering artificial microbial consortia for efficient lactic acid fermentation from undetoxified hydrolysates: from induced niche succession in a dual Bacillus coagulans consortium to Pseudomonas putida-assisted system reinforcement.Biotechnology for biofuels and bioproducts · 2026Article
- Burden-aware feedback control of microbial consortia.Nature communications · 2026Article
- Development and Assessment of Heavy Oil-Degrading Fungal Consortia (Journal of fungi (Basel, Switzerland) · 2026Article
- Seed endophytic bacteria from invasive Lactuca serriola increase soil available phosphorus under phosphorus deficiency.Scientific reports · 2026Article
- Exploring the biotechnological potential of terrestrial hot spring microbiomes for COEnvironmental microbiome · 2026Article
- Volatile fatty acids as sustainable precursors for bioproduction: advances in pathway engineering, and bioprocess optimization.World journal of microbiology & biotechnology · 2026Review
- Multi-omics provides functional insights and underscores practical challenges in assessing the composition and performance of a nitrifying microbial consortium.Applied and environmental microbiology · 2026Article
- Cooperativity in microbial biotechnology: synthetic consortia as emerging metabolic engineering strategy for sustainable bioproduction.Frontiers in bioengineering and biotechnology · 2026Review
- Metabolic interplay in a synthetic consortium: insights into the mediating role of a minority species.Frontiers in microbiology · 2026Article
- Microbial engineering for pesticide degradation: current insights and future directions for sustainable agriculture.Frontiers in microbiology · 2026Review
- Programmable cell differentiation in budding yeast uncouples reproductive and metabolic tasks.bioRxiv : the preprint server for biology · 2025Article
- A synthetic microbial community derived from healthy apple rhizosphere alleviates apple replant disease.Horticulture research · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
During microbial applications, metabolic burdens can lead to a significant drop in cell performance. Novel synthetic biology tools or multi-step bioprocessing (e.g., fermentation followed by chemical conversions) are therefore needed to avoid compromised biochemical productivity from over-burdened cells. A possible solution to address metabolic burden is Division of Labor (DoL) via natural and synthetic microbial consortia. In particular, consolidated bioprocesses and metabolic cooperation for detoxification or cross feeding (e.g., vitamin C fermentation) have shown numerous successes in industrial level applications. However, distributing a metabolic pathway among proper hosts remains an engineering conundrum due to several challenges: complex subpopulation dynamics/interactions with a short time-window for stable production, suboptimal cultivation of microbial communities, proliferation of cheaters or low-producers, intermediate metabolite dilution, transport barriers between species, and breaks in metabolite channeling through biosynthesis pathways. To develop stable consortia, optimization of strain inoculations, nutritional divergence and crossing feeding, evolution of mutualistic growth, cell immobilization, and biosensors may potentially be used to control cell populations. Another opportunity is direct integration of non-bioprocesses (e.g., microbial electrosynthesis) to power cell metabolism and improve carbon efficiency. Additionally, metabolic modeling and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.