ArticleBMC genomics2019
Virulence factor landscape of a Staphylococcus aureus sequence type 45 strain, MCRF184.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Genomic Characterization of a Rare Methicillin-Susceptible Staphylococcus aureus ST72 Isolate Co-Harboring Panton-Valentine Leukocidin and Toxic Shock Syndrome Toxin-1 Encoding Genes from Northern Vietnam.Current microbiology · 2026Article
- Diagnostic strategies in necrotizing soft tissue infections: from clinical scores to multi-omics and machine learning.Burns & trauma · 2026Review
- Dissecting the genetic features and evolution ofmSystems · 2024Article
- Genomic characteristics of cfr and fexA carrying Staphylococcus aureus isolated from pig carcasses in Korea.Veterinary research · 2024Article
- Comparative genome analyses of Staphylococcus aureus from platelet concentrates reveal rearrangements involving loss of type VII secretion genes.Access microbiology · 2024Article
- Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-ResistantPathogens (Basel, Switzerland) · 2023Article
- Article
- Molecular Evolution and Genomic Insights into Community-Acquired Methicillin-Resistant Staphylococcus aureus Sequence Type 88.Microbiology spectrum · 2022Article
- Case Report: Necrotizing fasciitis caused byFrontiers in genetics · 2022Article
- Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Bacteremia and Monocyte Evasion, Rio de Janeiro, Brazil.Emerging infectious diseases · 2021Article
- Genomic Analysis of GlobalFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundWe describe the virulence factors of a methicillin-sensitive Staphylococcus aureus sequence type (ST) 45 strain, MCRF184, (spa type t917), that caused severe necrotizing fasciitis in a 72-year-old diabetic male. The genome of MCRF184 possesses three genomic islands: a relatively large type III νSaα with 42 open reading frames (ORFs) that includes superantigen- and lipoprotein-like genes, a truncated νSaβ that consists mostly of the enterotoxin gene cluster (egc), and a νSaγ island with 18 ORFs including α-toxin. Additionally, the genome has two phage-related regions: phage φSa3 with three genes of the immune evasion cluster (IEC), and an incomplete phage that is distinct from other S. aureus phages. Finally, the region between orfX and orfY harbors a putative efflux pump, acetyltransferase, regulators, and mobilization genes instead of genes of SCCmec.
resultsVirulence factors included phenol soluble modulins (PSMs) α1 through α4 and PSMs β1 and β2. Ten ORFs identified in MCRF184 had not been reported in previously sequenced S. aureus strains.
conclusionThe dire clinical outcome in the patient and the described virulence factors all suggest that MCRF184, a ST45 strain is a highly virulent strain of S. aureus.
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