Evidence map›Paper›PMID 30736422›Full record

ArticleInternational journal of molecular sciences2019

CGRP Induces Differential Regulation of Cytokines from Satellite Glial Cells in Trigeminal Ganglia and Orofacial Nociception.

Shaista Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Oshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama, Yoshizo Matsuka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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  11. Association between serum high-sensitivity C-reactive protein levels and migraine: a REFORM study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shaista AfrozDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan. shaista_afroz@yahoo.com.
Rieko ArakakiDepartment of Oral Molecular Pathology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan. arakaki.r@tokushima-u.ac.jp.
Takuma IwasaDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan. c301551017@tokushima-u.ac.jp.
Masamitsu OshimaDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan. m-oshima@tokushima-u.ac.jp.
Maki HosokiDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan. hosoki@tokushima-u.ac.jp.ORCID 0000-0002-5275-2111
Miho InoueDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan. inoue.miho@tokushima-u.ac.jp.
Otto BabaDepartment of Oral and Maxillofacial Anatomy, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan. baba.otto@tokushima-u.ac.jp.
Yoshihiro OkayamaClinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima 770-8503, Japan. y-okayama@tokushima-u.ac.jp.
Yoshizo MatsukaDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan. matsuka@tokushima-u.ac.jp.
Tokushima University · JPTokushima University Hospital · JP

Funding

Ministry of Education Culture, Sports, Science and Technology of Japan No. 26293412, 18H02992
6 · The paper itself

Abstract

Neuron-glia interactions contribute to pain initiation and sustainment. Intra-ganglionic (IG) secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) modulates pain transmission through neuron-glia signaling, contributing to various orofacial pain conditions. The present study aimed to investigate the role of satellite glial cells (SGC) in TG in causing cytokine-related orofacial nociception in response to IG administration of CGRP. For that purpose, CGRP alone (10 μL of 10

Indexed as

NociceptionAnimalsCytokinesDisease Models, AnimalFacial PainHyperalgesiaMaleModels, BiologicalNeurogliaNeuronsRatsReceptors, Calcitonin Gene-Related PeptideTemperatureTrigeminal GanglionCytokinesReceptors, Calcitonin Gene-Related Peptidecalcitonin gene related peptidecytokinesatellite glial cellsthermal hyperalgesiatrigeminal ganglion

Identifiers

PMID30736422
PMCPMC6386987
OpenAlexW2912647362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.