Evidence map›Paper›PMID 30736414›Full record

ArticleMolecules (Basel, Switzerland)2019

Gelatin-Based Hydrogels through Homobifunctional Triazolinediones Targeting Tyrosine Residues.

Roberto Guizzardi, Luca Vaghi, Marcello Marelli, Antonino Natalello, Ivan Andreosso, Antonio Papagni, Laura Cipolla

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. 3DFrontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Roberto GuizzardiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano-IT, Italy. r.guizzardi@campus.unimib.it.
Luca VaghiDepartment of Materials Science, University of Milano-Bicocca, via R. Cozzi 55, 20125 Milano-IT, Italy. luca.vaghi@unimib.it.
Marcello MarelliCNR, Institute of Molecular Science and Technologies, Via C. Golgi 19, 20133 Milano-IT, Italy. m.marelli@istm.cnr.it.ORCID 0000-0003-3662-7326
Antonino NatalelloDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano-IT, Italy. antonino.natalello@unimib.it.ORCID 0000-0002-1489-272X
Ivan AndreossoDepartment of Materials Science, University of Milano-Bicocca, via R. Cozzi 55, 20125 Milano-IT, Italy. i.andreosso@campus.unimib.it.
Antonio PapagniDepartment of Materials Science, University of Milano-Bicocca, via R. Cozzi 55, 20125 Milano-IT, Italy. antonio.papagni@unimib.it.
Laura CipollaDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano-IT, Italy. laura.cipolla@unimib.it.ORCID 0000-0003-2678-8329
University of Milano-Bicocca · ITInstitute of Molecular Science and Technologies · IT

Funding

University of Milano - Bicocca Fondo di Ateneo (FA) 2018
6 · The paper itself

Abstract

Gelatin is a biopolymer with interesting properties that can be useful for biomaterial design for different applications such as drug delivery systems, or 3D scaffolds for tissue engineering. However, gelatin suffers from poor mechanical stability at physiological temperature, hence methods for improving its properties are highly desirable. In the present work, a new chemical cross-linking strategy based on triazolinedione ene-type chemistry towards stable hydrogel is proposed. Two different homobifunctional 1,2,4-triazoline-3,5(4

Indexed as

Biocompatible MaterialsDrug StabilityGelatinHydrogelsMaterials TestingMolecular StructureSpectroscopy, Fourier Transform InfraredTemperatureTriazolesTyrosineBiocompatible MaterialsGelatinHydrogelsTriazolesTyrosinechemical cross-linkingcyclic diazodicarboxamidesene-type chemistrygelatinhydrogelnatural polymerstriazolinedionestyrosine

Identifiers

PMID30736414
PMCPMC6385110
OpenAlexW2914864658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.