Evidence map›Paper›PMID 30736391›Full record

ArticleInternational journal of molecular sciences2019

Anti-Inflammatory Activity of A Polyphenolic Extract from

Roberto Mattioli, Antonio Francioso, Maria d'Erme, Maurizio Trovato, Patrizia Mancini, Lucia Piacentini, Assunta Maria Casale, Ludger Wessjohann, Roberta Gazzino, Paolo Costantino and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 55 citations in OpenAlex.

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  15. Silviridoside: A New Triterpene Glycoside fromMolecules (Basel, Switzerland) · 2022
    Article
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  20. Exploring Aβ Proteotoxicity and Therapeutic Candidates UsingInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Roberto MattioliDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Roma, Italy. roberto.mattioli@uniroma1.it.ORCID 0000-0002-4452-9753
Antonio FranciosoDepartment of Biochemical Sciences, Sapienza University of Rome, 00185 Roma, Italy. antonio.francioso@uniroma1.it.ORCID 0000-0001-9822-0260
Maria d'ErmeDepartment of Biochemical Sciences, Sapienza University of Rome, 00185 Roma, Italy. maria.derme@uniroma1.it.
Maurizio TrovatoDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Roma, Italy. maurizio.trovato@uniroma1.it.ORCID 0000-0002-3517-2617
Patrizia ManciniDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy. patrizia.mancini@uniroma1.it.ORCID 0000-0003-0556-2056
Lucia PiacentiniDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Roma, Italy. lucia.piacentini@uniroma1.it.ORCID 0000-0002-3656-5068
Assunta Maria CasaleDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Roma, Italy. assuntamaria.casale@uniroma1.it.
Ludger WessjohannDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany. Ludger.Wessjohann@ipb-halle.de.
Roberta GazzinoDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Roma, Italy. robertagazzino@gmail.com.ORCID 0000-0002-0304-5875
Paolo CostantinoDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Roma, Italy. paolo.costantino@uniroma1.it.
Luciana MoscaDepartment of Biochemical Sciences, Sapienza University of Rome, 00185 Roma, Italy. luciana.mosca@uniroma1.it.ORCID 0000-0003-2748-9021
Sapienza University of Rome · ITLeibniz Institute of Plant Biochemistry · DE

Funding

Finanziaria Laziale di Sviluppo FILAS-RU-2014-1020Ministero dell'Istruzione, dell'Università e della Ricerca PROS.IT CTN01_00230_413096Sapienza Università di Roma Ateneo 2015
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly. One of the main features of AD is the increase in amyloid-beta (Aβ) peptide production and aggregation, leading to oxidative stress, neuroinflammation and neurodegeneration. Polyphenols are well known for their antioxidant, anti-inflammatory and neuroprotective effects and have been proposed as possible therapeutic agents against AD. Here, we investigated the effects of a polyphenolic extract of

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnti-Inflammatory AgentsArabidopsisCell LineCell SurvivalChromatography, High Pressure LiquidCytokinesGene Expression RegulationHumansInflammation MediatorsLocomotionMass SpectrometryNeuronsNF-E2-Related Factor 2NF-kappa BAmyloid beta-PeptidesAnti-Inflammatory AgentsCytokinesInflammation MediatorsNF-E2-Related Factor 2NF-kappa BPhytochemicalsPlant ExtractsPolyphenolsAlzheimer’s diseaseamyloid betaArabidopsis thalianaBV2 cellsinterleukinsNF-κBNrf2polyphenols

Identifiers

PMID30736391
PMCPMC6387160
OpenAlexW2913160509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.