Evidence map›Paper›PMID 30736379›Full record

ArticleMolecules (Basel, Switzerland)2019

Design, Synthesis and Biological Evaluation of Nitrate Derivatives of Sauropunol A and B as Potent Vasodilatory Agents.

Lu Lu, Xuemin Rao, Rigang Cong, Chenxi Zhang, Zhimei Wang, Jinyi Xu, Genzoh Tanabe, Osamu Muraoka, Xiaoming Wu, Weijia Xie

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Lu LuState Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. 18851739997@163.com.
Xuemin RaoState Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. raochzh@163.com.
Rigang CongNational Certified Enterprise Technology Center, Disha Pharmaceutical Group Co., Ltd., Weihai 264205, China. crg1981@126.com.
Chenxi ZhangState Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. zcxciscy@163.com.
Zhimei WangState Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. 15295772843@163.com.
Jinyi XuState Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. jinyixu@cpu.edu.cn.
Genzoh TanabeFaculty of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan. g-tanabe@phar.kindai.ac.jp.ORCID 0000-0002-7954-8874
Osamu MuraokaFaculty of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan. muraoka@phar.kindai.ac.jp.
Xiaoming WuState Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. xmwu@cpu.edu.cn.
Weijia XieState Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. weijiaxie@cpu.edu.cn.
China Pharmaceutical University · CNKindai University · JPBetta Pharmaceuticals (China) · CN

Funding

National Natural Science Foundation of China 81473081, 81673312Natural Science Foundation of Jiangsu Province for outstanding young scholars BK20160078Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education 2013Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Personnel of China 2013
6 · The paper itself

Abstract

A group of nitrate derivatives of naturally occurring sauropunol A and B were designed and synthesized. Nitric oxide (NO) releasing capacity and vasodilatory capacity studies were performed to explore the structure-activity relationship of resulted nitrates. Biological evaluation of these compounds revealed that most of the synthesized mononitrate derivatives demonstrated superior releasing capacity than isosorbide mononitrate (ISMN), and

Indexed as

Drug DesignAnimalsChemistry Techniques, SyntheticIn Vitro TechniquesMesenteric ArteriesMolecular StructureNitratesNitric OxideRatsStructure-Activity RelationshipVasodilator AgentsNitratesNitric OxideVasodilator AgentsNO donorNO releasing capacitysauropunol A and BSauropus rostratusvasodilatory agents

Identifiers

PMID30736379
PMCPMC6384914
OpenAlexW2911961517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.