Evidence map›Paper›PMID 30736359›Full record

ArticleCells2019

Retroelement-Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution.

Daniil Nikitin, Andrew Garazha, Maxim Sorokin, Dmitry Penzar, Victor Tkachev, Alexander Markov, Nurshat Gaifullin, Pieter Borger, Alexander Poltorak, Anton Buzdin

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  8. Effect of the Expression ofFrontiers in genetics · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Daniil NikitinI.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia. danya.nikitin.orel@gmail.com.
Andrew GarazhaOmicsway Corp., Walnut, CA 91798, USA. garazha@oncobox.com.
Maxim SorokinI.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia. sorokin@oncobox.com.
Dmitry PenzarFaculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow 119992, Russia. dmitrypenzar1996@gmail.com.
Victor TkachevOmicsway Corp., Walnut, CA 91798, USA. tkachev@oncobox.com.
Alexander MarkovFaculty of Biology, Moscow State University, Moscow 119192, Russia. markov_a@inbox.ru.
Nurshat GaifullinFaculty of Fundamental Medicine, Moscow State University, Moscow 119992, Russia. gaifulin@rambler.ru.
Pieter BorgerLaboratory of the Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, Department of Surgery, University Hospital Zürich, Raemistrasse 100, Zürich CH-8091, Switzerland. pieter.borger@usz.ch.
Alexander PoltorakProgram in Immunology, Sackler Graduate School, Tufts University, Boston, MA 02111, USA. alexander.poltorak@tufts.edu.
Anton BuzdinI.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia. buzdin@oncobox.com.
Lomonosov Moscow State University · RUInstitute of Bioorganic Chemistry · RUDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology · RUSechenov University · RUTufts University · USUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRetroelements (REs) are transposable elements occupying ~40% of the human genome that can regulate genes by providing transcription factor binding sites (TFBS). RE-linked TFBS profile can serve as a marker of gene transcriptional regulation evolution. This approach allows for interrogating the regulatory evolution of organisms with RE-rich genomes. We aimed to characterize the evolution of transcriptional regulation for human genes and molecular pathways using RE-linked TFBS accumulation as a metric.

Indexed as

Biological EvolutionBinding SitesCell LineGene OntologyHumansProtein BindingRetroelementsTranscription FactorsRetroelementsTranscription FactorsChIP-seqgene ontologyHuman genome evolutionmolecular pathwaysomics approach in geneticsretrotransposonstranscription factor

Identifiers

PMID30736359
PMCPMC6406739
OpenAlexW2912647620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.