Evidence map›Paper›PMID 30736358›Full record

ArticleToxins2019

Treatment and Prevention of Recurrent Clostridium difficile Infection with Functionalized Bovine Antibody-Enriched Whey in a Hamster Primary Infection Model.

Hans-Jürgen Heidebrecht, William J Weiss, Mark Pulse, Anton Lange, Karina Gisch, Heike Kliem, Sacha Mann, Michael W Pfaffl, Ulrich Kulozik, Christoph von Eichel-Streiber

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Guideline
  2. Immunization Strategies Against Clostridioides difficile.Advances in experimental medicine and biology · 2024
    Review
  3. Article
  4. Review
  5. Frontiers in antibiotic alternatives forWorld journal of gastroenterology · 2021
    Article
  6. Review
  7. Alteration of Intestinal Microbiome ofAntibiotics (Basel, Switzerland) · 2021
    Article
  8. Article
  9. Anti-virulence strategies forGut microbes · 2020
    Review
  10. Prevention ofMicroorganisms · 2020
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Hans-Jürgen HeidebrechtChair of Food and Bioprocess Engineering, Technical University of Munich, 85354 Freising, Germany. Hans-Juergen.Heidebrecht@tum.de.
William J WeissUniversity of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA. William.Weiss@unthsc.edu.
Mark PulseUniversity of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA. Mark.Pulse@unthsc.edu.
Anton LangetgcBIOMICS GmbH, 55411 Bingen, Germany. a.lange@tgcbiomics.de.
Karina GischtgcBIOMICS GmbH, 55411 Bingen, Germany. k.gisch@tgcbiomics.de.
Heike KliemChair of Animal Physiology and Immunology, Technical University of Munich, 85354 Freising, Germany. kliem@wzw.tum.de.
Sacha MannBiosys UK Limited, London, SW1H, 9BP, UK. sacha.mann@gmail.com.ORCID 0000-0002-3888-2956
Michael W PfafflChair of Animal Physiology and Immunology, Technical University of Munich, 85354 Freising, Germany. michael.pfaffl@wzw.tum.de.ORCID 0000-0002-3192-1019
Ulrich KulozikChair of Food and Bioprocess Engineering, Technical University of Munich, 85354 Freising, Germany. ulrich.kulozik@tum.de.
Christoph von Eichel-StreibertgcBIOMICS GmbH, 55411 Bingen, Germany. chv.eichel@tgcbiomics.de.
Leibniz-Institute for Food Systems Biology at the Technical University of Munich · DETechnical University of Munich · DEUniversity of North Texas · USOsys Technology · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxin-induced

Indexed as

AnimalsAntibodiesBacterial ProteinsBacterial ToxinsBacterial VaccinesCattleClostridium InfectionsCricetinaeDisease Models, AnimalEnterotoxinsFemaleMaleMilkPregnancyWhey ProteinsAntibodiesBacterial ProteinsBacterial ToxinsBacterial VaccinesEnterotoxinstcdA protein, Clostridium difficiletoxB protein, Clostridium difficileWhey Proteinsbovine milkClostridium difficile infectionhamster model of CDIprevention of recurrencesIgA

Identifiers

PMID30736358
PMCPMC6409564
OpenAlexW2911784385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.