ArticlePharmaceutics2019
Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility.
Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Hot-melt extruded ibuprofen ternary solid dispersions using in-line UV-Vis: Impact of an ionizable polymer on thermodynamics and dissolution.International journal of pharmaceutics: X · 2026Article
- Advancing amorphous solid dispersions through empirical and hybrid modeling of drug-polymer solubility and miscibility: A case study using Ibuprofen.International journal of pharmaceutics: X · 2025Article
- Tabletability Enhancement of Acetaminophen Coated with a Nanocellulose Suspension using a Fluidized Bed.AAPS PharmSciTech · 2025Article
- Article
- Investigating the Effect of Basic Amino Acids and Glucosamine on the Solubility of Ibuprofen and Piroxicam.Advanced pharmaceutical bulletin · 2023Article
- Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds.Nanomaterials (Basel, Switzerland) · 2021Review
- Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA) Microcrystalline Solid Dispersion Films.AAPS PharmSciTech · 2020Article
- Dissolution Behavior of Flufenamic Acid in Heated Mixtures with Nanocellulose.Molecules (Basel, Switzerland) · 2020Article
- Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms.Pharmaceutics · 2020Article
- Immediate-Release Nifedipine Binary Dry Powder Mixtures with Nanocellulose Featuring Enhanced Solubility and Dissolution Rate.Pharmaceutics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The formulation of arylpropionic acid derivatives (profens), which are poorly soluble Biopharmaceutical Classification System (BCS) Type II drugs, has a strong impact on their therapeutic action. This article shows that heat-treated powder mixtures of free acid profens with high surface area Cladophora cellulose induces drug amorphization and results in enhanced solubility and bioavailability. Similar mixtures produced using conventional low surface area cellulose, i.e., microcrystalline cellulose, does not produce the same effect. The concept is thoroughly described and links the solid-state characterization data, such as differential scanning calorimetry, X-ray powder diffraction, and Fourier-transform infra-red spectroscopy, with in vitro dissolution in biorelevant media and in vivo pharmacokinetic analysis in rats. The concept is demonstrated for several substances from the profens group, including ibuprofen (main model drug), ketoprofen, flurbiprofen, and naproxen. The presented approach opens new ways to produce solid dosage forms of profen drugs in their free acidic form as alternatives to existing analogues, e.g., drug-salt conjugates or soft gel liquid capsules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.