Evidence map›Paper›PMID 30736331›Full record

ArticleNanomaterials (Basel, Switzerland)2019

Antioxidant Nanomaterial Based on Core⁻Shell Silica Nanospheres with Surface-Bound Caffeic Acid: A Promising Vehicle for Oxidation-Sensitive Drugs.

Francisco Arriagada, Germán Günther, Jaume Nos, Santi Nonell, Claudio Olea-Azar, Javier Morales

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Francisco ArriagadaDepartamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380494, Chile. farriagadajs@ug.uchile.cl.
Germán GüntherDepartamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380494, Chile. ggunther@ciq.uchile.cl.
Jaume NosInstitut Químic de Sarrià (IQS), University Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain. jaimenosa@iqs.url.edu.
Santi NonellInstitut Químic de Sarrià (IQS), University Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain. santi.nonell@iqs.url.edu.
Claudio Olea-AzarDepartamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380494, Chile. caolea@ciq.uchile.cl.
Javier MoralesDepartamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380494, Chile. javiermv@ciq.uchile.cl.
University of Chile · CLInstitut Químic de Sarrià · ES

Funding

Comisión Nacional de Investigación Científica y Tecnológica 21160932Fondo Nacional de Desarrollo Científico y Tecnológico 1160757Spanish Ministerio de Economía y Competitividad CTQ2016-78454-C2-1-R
6 · The paper itself

Abstract

The design of efficient, biocompatible, and easily prepared vehicles for drug delivery is a subject of great interest for medicine and pharmaceutical sciences. To achieve the above goals, surface functionalization is critical. Here, we report a hybrid nanocarrier consisting of core⁻shell silica nanospheres and the antioxidant caffeic acid linked to the surface, to evaluate their in vitro antioxidant capacity, their capability to protect oxidation-sensitive compounds incorporated in nanoparticles, and to study the interaction with bovine serum albumin protein. The results show that the radical-scavenging activity of immobilized caffeic acid is attenuated in the silica nanospheres; however, other antioxidant properties such as Fe

Indexed as

antioxidantcaffeic acidcore–shellnanocarrierpolyphenolssilica nanoparticlessinglet oxygen

Identifiers

PMID30736331
PMCPMC6409729
OpenAlexW2911310799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.