Evidence map›Paper›PMID 30736285›Full record

ArticleInternational journal of molecular sciences2019

Levels of Circulating Fibroblast Growth Factor 23 (FGF23) and Prognosis in Cancer Patients with Bone Metastases.

André Mansinho, Arlindo R Ferreira, Sandra Casimiro, Irina Alho, Inês Vendrell, Ana Lúcia Costa, Rita Sousa, Catarina Abreu, Catarina Pulido, Daniela Macedo and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Emerging concepts on the FGF23 regulation and activity.Molecular and cellular biochemistry · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Prognostic Value of Serum Soluble Klotho and Fibroblast Growth Factor-23 in Multiple Myeloma Patients.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2022
    Article
  12. The osteocyte as a signaling cell.Physiological reviews · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Role of Fibroblast Growth Factor 23 (FGF23) and αKlotho in Cancer.Frontiers in cell and developmental biology · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

André MansinhoMedical Oncology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. andr3.m@gmail.com.
Arlindo R FerreiraMedical Oncology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. ajrsferreira@gmail.com.
Sandra CasimiroLuís Costa Lab, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. scasimiro@medicina.ulisboa.pt.
Irina AlhoLuís Costa Lab, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. irina.mpmad@gmail.com.
Inês VendrellMedical Oncology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. inesvendrell@gmail.com.
Ana Lúcia CostaMedical Oncology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. c.ana.lucia4@gmail.com.
Rita SousaMedical Oncology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. arita.sousa@gmail.com.
Catarina AbreuMedical Oncology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. catarinaabreupm@hotmail.com.
Catarina PulidoOncology Department, Hospital da Luz, Lisbon, Portugal. pulido.catarina@gmail.com.
Daniela MacedoMedical Oncology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. danielavgmacedo@hotmail.com.
Teresa R PachecoMedical Oncology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. tr.pacheco@gmail.com.
Lurdes CorreiaPathology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. lucorreia.mail@sapo.pt.
Luís CostaMedical Oncology Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. luiscosta.oncology@gmail.com.
Centro Hospitalar Lisboa Norte · PTUniversity of Lisbon · PTHospital da Luz · PT

Funding

This research received funding from an anonymous non-pharma related individual in the form of donation. NA
6 · The paper itself

Abstract

The fibroblast growth factor (FGF) signaling pathway plays a key role in tumorigenesis and is recognized as a potential therapeutic target. In this study, the authors aimed to assess the impact of serum FGF23 levels in the prognosis of patients with cancer and bone metastases from solid tumors. A cohort of 112 patients with cancer and metastatic bone disease were treated with bone-targeted agents (BTA). Serum baseline FGF23 was quantified by ELISA and dichotomized in FGF23

Indexed as

Biomarkers, TumorAgedBone NeoplasmsFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasmsPrognosisProportional Hazards ModelsBiomarkers, TumorFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth Factorsbone metastasescancerFGF23prognosis

Identifiers

PMID30736285
PMCPMC6387099
OpenAlexW2912078781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.