Evidence map›Paper›PMID 30736096›Full record

Trial reportHematological oncology2019

Differential expression of estrogen receptor-α on follicular dendritic cells from patients with grade 1-2 and grade 3 follicular lymphoma.

Rintaro Ohe, Hong-Xue Meng, Naing Ye Aung, Akane Yamada, Takanobu Kabasawa, Aya Utsunomiya, Nobuyuki Tamazawa, Yuka Tamura, Takumi Kitaoka, Toshio Hashimoto and 5 more

Open access · hybridAbstract readClinical TrialComparative StudyMulticenter Study
In one paragraph

Trial report in Hematological oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
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  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Rintaro OheDepartment of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.ORCID https://orcid.org/0000-0002-8035-791X
Hong-Xue MengDepartment of Pathology, Harbin Medical University Cancer Hospital, Harbin, China.
Naing Ye AungDepartment of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
Akane YamadaDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Takanobu KabasawaDepartment of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
Aya UtsunomiyaDepartment of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
Nobuyuki TamazawaDepartment of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
Yuka TamuraDepartment of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
Takumi KitaokaDepartment of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
Toshio HashimotoDepartment of Surgery, Yonezawa City Hospital, Yonezawa, Japan.
Kenichi ShibataDepartment of Gastroenterological, General, Breast and Thyroid Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan.
Tomomi ToubaiDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Wataru KimuraDepartment of Surgery, Yonezawa City Hospital, Yonezawa, Japan.
Kenichi IshizawaDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Mitsunori YamakawaDepartment of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
Yamagata University · JPYonezawa Women's Junior College · JPHarbin Medical University · CN

Funding

Japan Society for the Promotion of Science JP17K08736
6 · The paper itself

Abstract

Hormone therapy has been used for patients with estrogen receptor alpha (ERα)-positive breast cancers. Recently, some studies reported the expression of ERα on neoplastic cells from B-cell lymphomas. However, there has been only one report of ERα expression on the follicular dendritic cells (FDCs) that structurally and functionally support the microenvironment of follicular lymphomas (FLs). The objective of this study was to investigate the frequency of ERα expression on FDCs in nonneoplastic reactive lymphoid tissues and to compare the frequency of ERα expression on FDCs in the axillary lymph nodes between patients with and without antiestrogen therapy and among patients with grades 1-3 of FL. Reverse transcription-polymerase chain reaction was performed to detect ERα mRNA in FL. In nonneoplastic germinal centers (GCs) from patients with tonsillitis or reactive lymphadenitis, ERα was expressed in the light zone. ERα-positive cells strongly correlated with the width of GCs (r

Indexed as

Gene Expression Regulation, NeoplasticDendritic Cells, FollicularEstrogen Receptor alphaFemaleHumansLymph NodesLymphoma, FollicularMaleNeoplasm GradingNeoplasm ProteinsESR1 protein, humanEstrogen Receptor alphaNeoplasm ProteinsCD23estrogen receptor alphafollicular dendritic cellfollicular lymphoma

Identifiers

PMID30736096
PMCPMC6593816
OpenAlexW2911391995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.