Evidence map›Paper›PMID 30736013›Full record

ArticleJournal of neural engineering2019

Parallel, minimally-invasive implantation of ultra-flexible neural electrode arrays.

Zhengtuo Zhao, Xue Li, Fei He, Xiaoling Wei, Shengqing Lin, Chong Xie

Open access · greenAbstract read
In one paragraph

Article in Journal of neural engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 111 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Fabrication and Validation of Sub-Cellular Carbon Fiber Electrodes.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024
    Article
  17. Article
  18. Real-time in vivo thoracic spinal glutamate sensing during myocardial ischemia.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhengtuo ZhaoDepartment of Biomedical Engineering, the University of Texas at Austin, Austin, TX 78712, United States of America.
Xue LiDepartment of Biomedical Engineering, the University of Texas at Austin, Austin, TX 78712, United States of America.
Fei HeDepartment of Biomedical Engineering, the University of Texas at Austin, Austin, TX 78712, United States of America.
Xiaoling WeiDepartment of Biomedical Engineering, the University of Texas at Austin, Austin, TX 78712, United States of America.
Shengqing LinDepartment of Biomedical Engineering, the University of Texas at Austin, Austin, TX 78712, United States of America.
Chong XieDepartment of Biomedical Engineering, the University of Texas at Austin, Austin, TX 78712, United States of America.ORCID 0000-0002-5544-2864
The University of Texas at Austin · US

Funding

A Nanoelectronic Strategy for Reliable, Large-scale Chronic Neural RecordingR01NS102917 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI Chong Xie · 2017 to 2026
$3.5M
NINDS NIH HHS R01 NS102917
6 · The paper itself

Abstract

objectiveImplanted microelectrodes provide a unique means to directly interface with the nervous system but have been limited by the lack of stable functionality. There is growing evidence suggesting that substantially reducing the mechanical rigidity of neural electrodes promotes tissue compatibility and improves their recording stability in both the short- and long-term. However, the miniaturized dimensions and ultraflexibility desired for mitigating tissue responses preclude the probe's self-supported penetration into the brain tissue. APPROACH: Here we demonstrate the high-throughput implantation of multi-shank ultraflexible neural electrode arrays with surgical footprints as small as 200 µm MAIN

resultsWe show the ability to simultaneously deliver electrode arrays in designed patterns, to adjust the implantation locations of the shanks by need, to target different brain structures, and to control the surgical injury by reducing the microwire diameters to cellular scale. SIGNIFICANCE: These results provide a facile implantation method to apply ultraflexible neural probes in scalable neural recording.

Indexed as

Electrodes, ImplantedStereotaxic TechniquesAnimalsBrainMaleMiceMice, Inbred C57BLMicroelectrodesMinimally Invasive Surgical ProceduresNeuronsPliability

Identifiers

PMID30736013
PMCPMC6506360
OpenAlexW2911873702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.