ArticleEnvironmental research2019
In utero metal exposures measured in deciduous teeth and birth outcomes in a racially-diverse urban cohort.
Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Assessing preterm infant metal exposures in shed teeth: findings from the Developmental Impact of NICU Exposures (DINE) study.Journal of exposure science & environmental epidemiology · 2026Article
- Article
- Lead exposure across the life course and age at death.The Science of the total environment · 2024Article
- Scientific opinion on the tolerable upper intake level for manganese.EFSA journal. European Food Safety Authority · 2023Article
- Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence.Biological psychiatry global open science · 2023Article
- Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil.International journal of environmental research and public health · 2023Article
- A permutation-based approach to inference for weighted sum regression with correlated chemical mixtures.Statistical methods in medical research · 2022Article
- Prenatal metal(loid) mixtures and birth weight for gestational age: A pooled analysis of three cohorts participating in the ECHO program.Environment international · 2022Article
- Prenatal metal mixture concentrations and reward motivation in children.Neurotoxicology · 2022Article
- Early pregnancy exposure to metal mixture and birth outcomes - A prospective study in Project Viva.Environment international · 2021Article
- Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting.Environmental research · 2021Article
- Prenatal metal mixtures and fetal size in mid-pregnancy in the MADRES study.Environmental research · 2021Article
- Prenatal exposure to multiple metals and birth outcomes: An observational study within the National Children's Study cohort.Environment international · 2021Observational
- Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles.Environmental health perspectives · 2020Article
- Birth outcomes associated with maternal exposure to metals from informal electronic waste recycling in Guiyu, China.Environment international · 2020Article
- Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
A growing number of studies have examined associations of metal exposures with birth outcomes, however, results from these studies have been inconsistent, and hampered by methodological limitations. We measured direct fetal exposure to three metals (lead, manganese and zinc) during the second and third trimester and examined its association with birth weight and gestational age at delivery. Participants in the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS), a population-based birth cohort established between September 2003 and December 2007, were invited to donate teeth to the study. Lead, manganese and zinc during the second and third trimesters were measured via high-resolution microspatial mapping of dentin growth rings, a validated biomarker for prenatal metal exposure. Gestational age at delivery and infant birth weight were obtained from the delivery medical record. A total of 145 children had tooth metal measurements and birth outcome data. Mean birth weight was 3431 ± 472 g and mean gestational age at delivery was 39.0 ± 1.3 weeks. Overall, there was a positive association between second (β = 0.21, 95% CI: 0.05, 0.37, P = 0.01) and third trimester (β = 0.21, 95% CI: 0.05, 0.37, P = 0.01) tooth manganese and birth weight Z-score; this remained statistically significant after covariate adjustment. There was also a negative association between second trimester tooth lead level and birth weight Z-score (β = -0.20, 95% CI: -0.38, -0.02, P = 0.02), however, this was attenuated after adjusting for covariates. Mixture analysis revealed similar findings. There was evidence for a sex-specific effect of manganese with birth weight Z-score, with the association stronger in female compared to male infants. Overall, we found evidence suggesting that higher in utero manganese is associated with larger birth weight Z-scores and that these associations may vary by infant sex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.