ArticleiScience2019
Electrochemical Oxidative Clean Halogenation Using HX/NaX with Hydrogen Evolution.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 163 citations in OpenAlex.
- Electrochemical synthesis of 2-oxa-bicyclo[2.1.1]hexanes by anodic oxidation-cyclization relay strategy.Chemical science · 2026Article
- Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90.Nature communications · 2025Article
- Pt/IrONature communications · 2025Article
- Aminoborate-Catalyzed Reductive Counterreactions for Oxidative Electrosynthetic Transformations.The Journal of organic chemistry · 2024Article
- Electrochemical Bromination of Arenes in a 200% Cell.The Journal of organic chemistry · 2024Article
- Alkynes Electrooxidation to α,α-Dichloroketones in Seawater with Natural Chlorine Participation via Competitive Reaction Inhibition and Tip-Enhanced Reagent Concentration.ACS central science · 2024Article
- Electrochemical Late-Stage Functionalization.Chemical reviews · 2023Review
- Controlling Selectivity in Shuttle Hetero-difunctionalization Reactions: Electrochemical Transfer Halo-thiolation of Alkynes.Angewandte Chemie (International ed. in English) · 2023Article
- Distal Ruthenaelectro-Catalyzed meta-C-H Bromination with Aqueous HBr.Angewandte Chemie (International ed. in English) · 2022Article
- Recent advances in metal catalyst- and oxidant-free electrochemical C-H bond functionalization of nitrogen-containing heterocycles.Frontiers in chemistry · 2022Review
- Photoelectrocatalytic C-H halogenation over an oxygen vacancy-rich TiONature communications · 2021Article
- Linear Paired Electrolysis-Realising 200 % Current Efficiency for Stoichiometric Transformations-The Electrochemical Bromination of Alkenes.Angewandte Chemie (International ed. in English) · 2021Article
- Review
- Electrochemical Bromination of Glycals.Frontiers in chemistry · 2021Article
- Tungstate-Catalyzed Biomimetic Oxidative Halogenation of (Hetero)Arene under Mild Condition.iScience · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organic halides (R-X) are prevalent structural motifs in pharmaceutical molecules and key building blocks for the synthesis of fine chemicals. Although a number of routes are available in the literature for the synthesis of organic halides, these methods often require stoichiometric additives or oxidants, metal catalysts, leaving or directing groups, or toxic halogenating agents. In addition, the necessity of employing different, often tailor-made, catalytic systems for each type of substrate also limits the applicability of these methods. Herein, we report a clean halogenation by electrochemical oxidation with NaX/HX. A series of organic halides were prepared under metal catalyst- and exogenous-oxidant-free reaction conditions. It is worth noting that this reaction has a broad substrate scope; various heteroarenes, arenes, alkenes, alkynes, and even aliphatic hydrocarbons could be applied. Most importantly, the reaction could also be performed on a 200-mmol scale with the same efficiency (86%, 50.9 g pure product).
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