Evidence map›Paper›PMID 30735637›Full record

ArticleCell2019

Impairment of an Endothelial NAD

Abhirup Das, George X Huang, Michael S Bonkowski, Alban Longchamp, Catherine Li, Michael B Schultz, Lynn-Jee Kim, Brenna Osborne, Sanket Joshi, Yuancheng Lu and 12 more

Abstract readPublished Erratum
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Natural Variation ofInternational journal of molecular sciences · 2025
    Article
  9. Protein Acetylation and NAD+ Homeostasis in Aging Muscle.Advances in experimental medicine and biology · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. High level expression of nicotinamide nucleoside kinase fromFrontiers in bioengineering and biotechnology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Abhirup Das
George X Huang
Michael S Bonkowski
Alban Longchamp
Catherine Li
Michael B Schultz
Lynn-Jee Kim
Brenna Osborne
Sanket Joshi
Yuancheng Lu
Jose Humberto Treviño-Villarreal
Myung-Jin Kang
Tzong-Tyng Hung
Brendan Lee
Eric O Williams
Masaki Igarashi
James R Mitchell
Lindsay E Wu
Nigel Turner
Zolt Arany
Leonard Guarente
David A Sinclair

Funding

Role of Sgs1 DNA helicase in telomere maintenanceR01AG019719 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SINCLAIR, DAVID A. · 2001 to 2022
$5.3M
SIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1M
Elucidating mechanisms of SIRT1 activationR01DK100263 · NIDDK · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2016 to 2020
$2.5M
NIA NIH HHS R01 AG019719NIA NIH HHS R37 AG028730NIDDK NIH HHS R01 DK100263
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID30735637
PMCPMC6429953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.