ArticleCell2019
Small-Molecule Agonists of Ae. aegypti Neuropeptide Y Receptor Block Mosquito Biting.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 119 citations in OpenAlex.
- Behavioral determinants of disease transmission by mosquitoes.Current opinion in insect science · 2026Review
- Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience inNAR genomics and bioinformatics · 2026Article
- Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents.Pest management science · 2026Article
- Two neuropeptides that promote blood feeding ineLife · 2026Article
- A negative survival pressure selection system enables GPCR antagonist screening.Cell discovery · 2026Article
- Behavioral heterogeneity in host seeking and post-feeding suppression among disease vector mosquitoes.Communications biology · 2026Article
- A signaling hub in the mosquito rectum coordinates reproductive investment after blood feeding.Current biology : CB · 2026Article
- The circadian clock gene CYCLE as a potential target for disrupting blood-feeding behavior in the mosquito Culex pipiens.PLoS neglected tropical diseases · 2026Article
- Integrated In Silico, In Vivo, and Deep Learning Approaches in the Discovery of Novel Candidate Molecules for Aedes aegypti Control.Archives of insect biochemistry and physiology · 2026Article
- Characterization and deorphanization of RYamide signaling in Aedes aegypti: A potential regulator of hindgut-associated physiology.PloS one · 2026Article
- Post-biting behavioral reprogramming underlies reproductive efficiency in Aedes aegypti mosquitoes.Cell reports · 2025Article
- Article
- A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025Article
- A Signaling Hub in the Mosquito Rectum Coordinates Reproductive Investment After Blood Feeding.bioRxiv : the preprint server for biology · 2025Article
- Post-biting behavioral reprogramming underlies reproductive efficiency inbioRxiv : the preprint server for biology · 2025Article
- Behavioral heterogeneity in host-seeking and post-feeding suppression among disease vector mosquitoes.bioRxiv : the preprint server for biology · 2025Article
- Comparative Perspectives on Neuropeptide Function and Social Isolation.Biological psychiatry · 2025Review
- Optimized genetic tools for neuroanatomical and functional mapping of the Aedes aegypti olfactory system.G3 (Bethesda, Md.) · 2025Article
- Article
- A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.Nature communications · 2024Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
Female Aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. Remarkably, their strong attraction to humans is suppressed for days after the blood meal by an unknown mechanism. We investigated a role for neuropeptide Y (NPY)-related signaling in long-term behavioral suppression and discovered that drugs targeting human NPY receptors modulate mosquito host-seeking. In a screen of all 49 predicted Ae. aegypti peptide receptors, we identified NPY-like receptor 7 (NPYLR7) as the sole target of these drugs. To obtain small-molecule agonists selective for NPYLR7, we performed a high-throughput cell-based assay of 265,211 compounds and isolated six highly selective NPYLR7 agonists that inhibit mosquito attraction to humans. NPYLR7 CRISPR-Cas9 null mutants are defective in behavioral suppression and resistant to these drugs. Finally, we show that these drugs can inhibit biting and blood-feeding on a live host, suggesting a novel approach to control infectious disease transmission by controlling mosquito behavior. VIDEO ABSTRACT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.