Evidence map›Paper›PMID 30735630›Full record

ArticleCell2019

Replication Timing Becomes Intertwined with 3D Genome Organization.

Jian Ma, Zhijun Duan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Control of DNA replication timing in the 3D genome.Nature reviews. Molecular cell biology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jian MaComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: jianma@cs.cmu.edu.
Zhijun DuanInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Division of Hematology, Department of Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address: zjduan@uw.edu.

Funding

University of Washington Center for Nuclear Organization and FunctionU54DK107979 · NIDDK · UNIVERSITY OF WASHINGTON · PI NOBLE, WILLIAM STAFFORD, SHENDURE, JAY ASHOK · 2015 to 2019
$11.8M
Mapping Technology DevelopmentU54DK107965 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BELMONT, ANDREW STEVEN · 2015 to 2019
$8.6M
Impact of Methamphetamine Use on the HIV Nucleome in Individuals on Antiretroviral TherapyR61DA047010 · NIDA · UNIVERSITY OF WASHINGTON · PI DUAN, ZHIJUN, MULLINS, JAMES IVAN · 2018 to 2020
$3.1M
Computational Methods for Next-Generation Comparative GenomicsR01HG007352 · NHGRI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MA, JIAN · 2014 to 2023
$2.8M
NHGRI NIH HHS R01 HG007352NIDA NIH HHS R61 DA047010NIDDK NIH HHS U54 DK107965NIDDK NIH HHS U54 DK107979
6 · The paper itself

Abstract

Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization. The study has important implications for unraveling control elements of high-order genome structure and function.

Indexed as

DNA ReplicationDNA Replication TimingAnimalsGenomeMammals

Identifiers

PMID30735630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.