Evidence map›Paper›PMID 30735434›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2019

TRPA1 channel contributes to myocardial ischemia-reperfusion injury.

Daniel J Conklin, Yiru Guo, Matthew A Nystoriak, Ganapathy Jagatheesan, Detlef Obal, Peter J Kilfoil, Joseph David Hoetker, Luping Guo, Roberto Bolli, Aruni Bhatnagar

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guidelines for in vivo mouse models of myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2021
    Guideline
  2. Article
  3. Stretch-Induced Increase in CaJournal of the American Heart Association · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Research Progress on TRPA1 in Diseases.The Journal of membrane biology · 2023
    Review
  10. The Dysfunction of CaInternational journal of molecular sciences · 2023
    Review
  11. Article
  12. TRPA1 as Target in Myocardial Infarction.International journal of molecular sciences · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. No functional TRPA1 in cardiomyocytes.Acta physiologica (Oxford, England) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel J ConklinDiabetes and Obesity Center, University of Louisville , Louisville, Kentucky.
Yiru GuoInstitute of Molecular Cardiology, University of Louisville , Louisville, Kentucky.
Matthew A NystoriakDiabetes and Obesity Center, University of Louisville , Louisville, Kentucky.
Ganapathy JagatheesanDiabetes and Obesity Center, University of Louisville , Louisville, Kentucky.
Detlef ObalDiabetes and Obesity Center, University of Louisville , Louisville, Kentucky.
Peter J KilfoilSmidt Heart Institute, Cedars-Sinai Hospital , Los Angeles, California.
Joseph David HoetkerDiabetes and Obesity Center, University of Louisville , Louisville, Kentucky.
Luping GuoDiabetes and Obesity Center, University of Louisville , Louisville, Kentucky.
Roberto BolliDiabetes and Obesity Center, University of Louisville , Louisville, Kentucky.
Aruni BhatnagarDiabetes and Obesity Center, University of Louisville , Louisville, Kentucky.

Funding

Superfund Training CoreP42ES023716 · NIEHS · UNIVERSITY OF LOUISVILLE · PI FORTNER, JOHN · 2017 to 2025
$18.1M
Project 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI DEFILIPPIS, ANDREW · 2012 to 2017
$13.8M
TBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2018 to 2022
$6.3M
Cardiovascular Toxicity of Tobacco Products and ConstituentsR01HL122676 · NHLBI · UNIVERSITY OF LOUISVILLE · PI CONKLIN, DANIEL JOSEPH · 2015 to 2019
$3.7M
Regulation of Coronary Blood FlowR01HL142710 · NHLBI · UNIVERSITY OF LOUISVILLE · PI NYSTORIAK, MATTHEW A · 2018 to 2022
$3.1M
NHLBI NIH HHS R01 HL122676NHLBI NIH HHS R01 HL142710NIEHS NIH HHS P42 ES023716NIGMS NIH HHS P20 GM103492NIGMS NIH HHS P30 GM127607
6 · The paper itself

Abstract

Myocardial ischemia-reperfusion (I/R) results in the generation of free radicals, accumulation of lipid peroxidation-derived unsaturated aldehydes, variable angina (pain), and infarction. The transient receptor potential ankyrin 1 (TRPA1) mediates pain signaling and is activated by unsaturated aldehydes, including acrolein and 4-hydroxynonenal. The contribution of TRPA1 (a Ca

Indexed as

AcetanilidesAldehydesAnimalsCalciumCells, CulturedMaleMiceMice, Inbred C57BLMyocardial ContractionMyocardial Reperfusion InjuryMyocytes, CardiacPurinesTRPA1 Cation Channel2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamideAcetanilidesAldehydesCalciumPurinesTRPA1 Cation ChannelTrpa1 protein, mouseacroleincardiomyocyteslipid peroxidationmyocardial infarctiontransient receptor potential ankyrin 1 channelunsaturated aldehydes

Identifiers

PMID30735434
PMCPMC6483018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.