ArticleeLife2019
PUMILIO hyperactivity drives premature aging of
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 94 citations in OpenAlex.
- The NORAD-Pumilio regulatory axis in the evolution of inclusion body myositis.Journal of neuropathology and experimental neurology · 2026Article
- RNA-Lexis: a probabilistic algorithm using a non-parametric segmentation logic to detect meaningful sequences in RNA.Nucleic acids research · 2026Article
- PUM1 and PUM2 promote translation of chromatin regulators to ensure mammalian spermatogenesis.Science advances · 2026Article
- Puf4 is methylated and exhibits a temperature-dependent interactome inMicrobiology spectrum · 2026Article
- Article
- Basophils activate splenic B cells and dendritic cells via IL-13 signaling in acute traumatic brain injury.Journal of neuroinflammation · 2025Article
- The syntenic long non-coding RNA DANCR is an essential regulator of zebrafish development and a human melanoma oncogene.PLoS genetics · 2025Article
- PUM2 binds SARS-CoV-2 RNA and PUM1 mildly reduces viral RNA levels, but neither protein affects progeny virus production.The Journal of general virology · 2025Article
- HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways.bioRxiv : the preprint server for biology · 2025Article
- Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity.Nature structural & molecular biology · 2025Article
- lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3.Nature communications · 2025Article
- SENP1 inhibits aerobic glycolysis in AβCell biology and toxicology · 2025Article
- LncRNA CHRF: molecular mechanisms and therapeutic potentials in cardiovascular diseases, cancers and fibrosis.Frontiers in cell and developmental biology · 2025Review
- Systematic analysis of the target recognition and repression by the Pumilio proteins.Nucleic acids research · 2024Article
- Regulation of synapse density by Pumilio RNA-binding proteins.Cell reports · 2024Article
- Article
- Long noncoding RNAs as versatile molecular regulators of cellular stress response and homeostasis.Human genetics · 2024Review
- Noncoding RNA Contribution to Aging and Lifespan.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- TREX reveals proteins that bind to specific RNA regions in living cells.Nature methods · 2024Article
- RNA binding protein PUM2 promotes IL-1β-induced apoptosis of chondrocytes via regulating FOXO3 expression.Heliyon · 2024Article
Corrections and comments
- Commented on byAging well with2019
Authors and funding
13 authors at 4 institutions in 1 country.
Florian KoppDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0001-9952-635X
Mahmoud M Elguindy *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0001-9151-1751
Mehmet E Yalvac *Center for Gene Therapy, Nationwide Children's Hospital, Columbus, United States.
He ZhangQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, United States.
Beibei ChenQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, United States.
Frank A GillettDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Sungyul LeeDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0003-3207-1199
Sushama SivakumarDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0001-7877-4821
Hongtao YuDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-8861-049X
Yang XieQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, United States.
Prashant MishraChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Zarife SahenkCenter for Gene Therapy, Nationwide Children's Hospital, Columbus, United States.
Joshua T MendellDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0001-8479-2284
The University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · USNationwide Children's Hospital · USChildren's Medical Center · US
Funding
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7MUniversity of Texas Southwestern Medical Center SPORE in Kidney CancerP50CA196516 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI James Brugarolas · 2016 to 2026
$24.7MThe intersection of RNA biology and tumor biologyR35CA197311 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MENDELL, JOSHUA T · 2015 to 2021
$5.1MCancer Prevention and Research Institute of Texas RP150596Cancer Prevention and Research Institute of Texas RP160249German National Academy of Sciences Leopoldina LPDS 2014-12NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA196516NCI NIH HHS R35 CA197311NIH HHS P30CA142543NIH HHS P50CA196516NIH HHS R35CA197311Welch Foundation I-1961-20180324
Abstract
Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function of the conserved lncRNA
Indexed as
AgingAging, PrematureAnimalsGene Expression RegulationHomeostasisHumansMiceMitochondriaMitosisPhenotypeRNA-Binding ProteinsRNA, Long NoncodingTranscription FactorsNORAD long non-coding RNA, humanPum2 protein, mouseRNA-Binding ProteinsRNA, Long NoncodingTranscription Factorsagingchromosomesgene expressiongeneticsgenomicsgenomic stabilityhumanlong noncoding RNAmitochondriamouseNoradPUMILIO
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.