Evidence map›Paper›PMID 30734850›Full record

ArticlePediatric nephrology (Berlin, Germany)2019

Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup.

Rupesh Raina, Stephanie Lam, Hershita Raheja, Vinod Krishnappa, Daljit Hothi, Andrew Davenport, Deepa Chand, Gaurav Kapur, Franz Schaefer, Sidharth Kumar Sethi and 4 more

Abstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Observational
  5. Review
  6. Medical device regulation and dialysis practice-impact on patients, doctors and manufacturers.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Pediatric acute kidney injury: new advances in the last decade.Kidney research and clinical practice · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 5 countries.

Rupesh RainaDepartment of Nephrology, Cleveland Clinic Akron General and Akron Children's Hospital, Akron, OH, USA. rraina@akronchildrens.org.ORCID 0000-0003-3892-8376
Stephanie LamDepartment of Pediatrics, Akron Children's Hospital, Akron, OH, USA.
Hershita RahejaThe Children's Hospital of New Jersey, Newark Beth Israel Medical Center, Newark, NJ, USA.
Vinod KrishnappaAkron Nephrology Associates/Cleveland Clinic Akron General, Akron, OH, USA.
Daljit HothiDepartment of Paediatric Nephrology, Great Ormond Street Hospital, Great Ormond Street, London, UK.
Andrew DavenportUCL Centre for Nephrology, Royal Free Hospital, University College London, London, UK.
Deepa ChandDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Gaurav KapurPediatric Nephrology and Hypertension, Children's Hospital of Michigan, Detroit, MI, USA.
Franz SchaeferPediatric Nephrology Division, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Sidharth Kumar SethiPediatric Nephrology & Pediatric Kidney Transplantation, Kidney and Urology Institute, Medanta, The Medicity Hospital, Gurgaon, India.
Mignon McCullochRed Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Arvind BaggaDivision of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Timothy BunchmanPediatric Nephrology & Transplantation, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, USA.
Bradley A WaradyDivision of Nephrology, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.
Cleveland Clinic · USAkron Children's Hospital · USAll India Institute of Medical Sciences · INChildren's Hospital of Michigan · USGreat Ormond Street Hospital · GBHeidelberg University · DEMedanta The Medicity · INNewark Beth Israel Medical Center · USThe Royal Free Hospital · GBUniversity of Cape Town · ZAUniversity of Missouri–Kansas City · USVirginia Commonwealth University · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intradialytic hypotension (IDH) is a common adverse event resulting in premature interruption of hemodialysis, and consequently, inadequate fluid and solute removal. IDH occurs in response to the reduction in blood volume during ultrafiltration and subsequent poor compensatory mechanisms due to abnormal cardiac function or autonomic or baroreceptor failure. Pediatric patients are inherently at risk for IDH due to the added difficulty of determining and attaining an accurate dry weight. While frequent blood pressure monitoring, dialysate sodium profiling, ultrafiltration-guided blood volume monitoring, dialysate cooling, hemodiafiltration, and intradialytic mannitol and midodrine have been used to prevent IDH, they have not been extensively studied in pediatric population. Lack of large-scale studies on IDH in children makes it difficult to develop evidence-based management guidelines. Here, we aim to review IDH preventative strategies in the pediatric population and outlay recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup. Without strong evidence in the literature, our recommendations from the expert panel reflect expert opinion and serve as a valuable guide.

Indexed as

ConsensusAge FactorsBlood PressureBlood Pressure DeterminationChildContinuous Renal Replacement TherapyHemodiafiltrationHemodialysis SolutionsHumansHypotensionKidney Failure, ChronicMidodrineRenal DialysisTemperatureHemodialysis SolutionsMidodrineBlood pressure monitoringBlood volume monitoringChildrenDialysate coolingIntradialytic hypotensionMannitolMidodrineSodium profiling

Identifiers

PMID30734850
OpenAlexW2911322656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.