Evidence map›Paper›PMID 30734697›Full record

ArticleThe American journal of tropical medicine and hygiene2019

Genetic Markers of Benzimidazole Resistance among Human Hookworms (

Ambrose R Orr, Josephine E Quagraine, Peter Suwondo, Santosh George, Lisa M Harrison, Fabio Pio Dornas, Benjamin Evans, Adalgisa Caccone, Debbie Humphries, Michael D Wilson and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ambrose R OrrYale Partnerships for Global Health, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Josephine E QuagraineDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Peter SuwondoYale Partnerships for Global Health, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Santosh GeorgeYale Partnerships for Global Health, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Lisa M HarrisonYale Partnerships for Global Health, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Fabio Pio DornasYale Partnerships for Global Health, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Benjamin EvansDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut.
Adalgisa CacconeDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut.
Debbie HumphriesDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut.
Michael D WilsonDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Michael CappelloYale Partnerships for Global Health, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Yale New Haven Health System · USYale University · USNoguchi Memorial Institute for Medical Research · GH

Funding

Emerging benzimidazole resistance in human hookwormsR01AI132452 · NIAID · YALE UNIVERSITY · PI CAPPELLO, MICHAEL · 2017 to 2021
$2.1M
NIAID NIH HHS R01 AI132452
6 · The paper itself

Abstract

Hookworm infection causes anemia, malnutrition, and growth delay, especially in children living in sub-Saharan Africa. The World Health Organization recommends periodic mass drug administration (MDA) of anthelminthics to school-age children (SAC) as a means of reducing morbidity. Recently, questions have been raised about the effectiveness of MDA as a global control strategy for hookworms and other soil-transmitted helminths (STHs). Genomic DNA was extracted from

Indexed as

Polymorphism, Single NucleotideAnimalsAnthelminticsBenzimidazolesChildCross-Sectional StudiesDrug ResistanceFemaleGene ExpressionGenetic MarkersGhanaHelminth ProteinsHookworm InfectionsHumansMaleMass Drug AdministrationAnthelminticsBenzimidazolesGenetic MarkersHelminth ProteinsTubulin

Identifiers

PMID30734697
PMCPMC6367626
OpenAlexW2905052612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.