ArticleThe American journal of tropical medicine and hygiene2020
Efficacy of Mass Azithromycin Distribution for Reducing Childhood Mortality Across Geographic Regions.
Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Secondary Effects from Mass Azithromycin Administration: A Systematic Review and Meta-analysis.The American journal of tropical medicine and hygiene · 2022Pooled it
- Trial
- Distance to Health Centers and Effectiveness of Azithromycin Mass Administration for Children in Niger: A Secondary Analysis of the MORDOR Cluster Randomized Trial.JAMA network open · 2023Trial
- Mass azithromycin for prevention of child mortality among children with acute malnutrition: A subgroup analysis of a cluster randomized controlled trial.PLOS global public health · 2024Article
- Mass drug administration of antibacterials: weighing the evidence regarding benefits and risks.Infectious diseases of poverty · 2022Review
- Azithromycin for uncomplicated severe acute malnutrition: study protocol for a pilot randomized controlled trial.Pilot and feasibility studies · 2021Article
- Effect Modification by Baseline Mortality in the MORDOR Azithromycin Trial.The American journal of tropical medicine and hygiene · 2020Article
- Optimizing the Number of Child Deaths Averted with Mass Azithromycin Distribution.The American journal of tropical medicine and hygiene · 2020Article
- Mass Drug Administration of Azithromycin to Reduce Child Mortality: Only for High-Mortality Settings?The American journal of tropical medicine and hygiene · 2020Article
- Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Mass azithromycin distribution has been shown to reduce all-cause mortality in preschool children in sub-Saharan Africa. However, substantial heterogeneity in the apparent effect has been noted across geographic settings, suggesting a greater relative benefit in higher mortality settings. Here, we evaluated the relationship between the underlying mortality rate and the efficacy of azithromycin for the prevention of child mortality using data from multiple sites in Ethiopia, Malawi, Niger, and Tanzania. Between regions, we find no strong evidence of effect modification of the efficacy of azithromycin distribution for the prevention of child mortality by the underlying mortality rate (
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Registered trials
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