Evidence map›Paper›PMID 30734636›Full record

ArticlePharmaceutical biology2019

Inhibitory effects of fucoidan on NMDA receptors and l-type Ca

Hong Wu, Shuibo Gao, Susumu Terakawa

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Hong Wua Laboratory of Cell Imaging , Henan University of Chinese Medicine , Zhengzhou , China.
Shuibo Gaoa Laboratory of Cell Imaging , Henan University of Chinese Medicine , Zhengzhou , China.
Susumu Terakawab Photon Medical Research Center , Hamamatsu University School of Medicine , Hamamatsu , Japan.
Hamamatsu University School of Medicine · JPFirst Affiliated Hospital of Henan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextFucoidan, a sulphated polysaccharide extracted from brown algae [Fucus vesiculosus Linn. (Fucaceae)], has multiple biological activities.

objectiveThe effects of fucoidan on Ca MATERIALS AND

methodsThe neurons isolated from the cortex and hippocampi of Wistar rats in postnatal day 1 were employed. The intracellular Ca

resultsThe Ca DISCUSSION AND

conclusionsOur data indicate that fucoidan suppresses the intracellular Ca

Indexed as

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsCalciumCalcium Channels, L-TypeCells, CulturedCerebellar CortexExcitatory Amino Acid AgonistsGlutamic AcidHippocampusNeuronsN-MethylaspartatePolysaccharidesRatsRats, WistarReceptors, AMPAReceptors, Glutamate3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterCalciumCalcium Channels, L-TypeExcitatory Amino Acid AgonistsfucoidanGlutamic AcidN-MethylaspartateNR1 NMDA receptorPolysaccharidesReceptors, AMPAReceptors, GlutamateReceptors, N-Methyl-D-AspartateCa transientCortical and hippocampal neuronmRNA expression of PR1/PR2sulphated polysaccharide

Identifiers

PMID30734636
PMCPMC6374951
OpenAlexW2913691043

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.