ReviewJournal of enzyme inhibition and medicinal chemistry2019
A comprehensive review on tyrosinase inhibitors.
Review in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 347 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
347 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of cosmetic whitening ingredients' lipophilicity on melanocyte cytotoxicity: A systematic review.Journal of food and drug analysis · 2026Pooled it
- Efficacy of formulations for treating hyperpigmentation: a systematic review and meta-analysis.Archives of dermatological research · 2025Pooled it
- Apple oil as a source of ursolic acid for the treatment of hyperpigmentary disorders with molecular and clinical evaluation.Scientific reports · 2025Trial
- Quinazoline-tethered thiazolo[3,2-RSC advances · 2026Article
- Synthesis, Biological Evaluation, Molecular Docking and DFT Studies of Electronically Tuned Benzylidene-Based Schiff Bases.Molecules (Basel, Switzerland) · 2026Article
- tris-Schiff Base Derivatives Containing Flurbiprofen as Potential Tyrosinase Inhibitors: Synthesis, In Vitro Evaluation, Molecular Docking, DFT and Dynamics Simulations.Chemistry & biodiversity · 2026Article
- Tunlametinib Suppresses Melanogenesis Induces Cell Cycle Arrest and Apoptosis in Giant Congenital Melanocytic Nevus Cells.Cancers · 2026Article
- An Integrated Metabolomics and Bioactivity Approach to Characterize Salvia heldreichiana and Salvia tomentosa Extracts.ChemistryOpen · 2026Article
- Production of Anti-melanogenic Glucosides via Molecular Docking-guided Biotransformation of p-hydroxyphenethyl anisate.Applied biochemistry and biotechnology · 2026Article
- Comparative Analysis of Chemical Composition and Bioactivities of Essential Oils From Different Parts of Wild-Grown Alpinia siamensis K.Schum. in Vietnam.Chemistry & biodiversity · 2026Article
- Bioactive Phenolics of Lygeum spartum L.: Insights Into Antioxidant, Anticholinesterase, and Antityrosinase Activities.Chemistry & biodiversity · 2026Article
- Ampyrone is a direct agonist of human tyrosinase and a potential therapeutic for hypopigmentation disorders.JCI insight · 2026Article
- Dietary Black Soldier Fly Larvae Meal Improves Growth Performance and Meat Quality Associated with Enhanced Antioxidant Capacity and Intestinal Health in Wenchang Chickens.Animals : an open access journal from MDPI · 2026Article
- Structural Dynamics and Susceptibility of Aminonaphthoquinone-Chalcone Hybrids Against Human Tyrosinase.International journal of molecular sciences · 2026Article
- Design and computational evaluation ofRSC advances · 2026Article
- Ganoderic Acid A Reverses Ultraviolet B Induced Hyperpigmentation via Multi-Targeted Regulation of Mitochondrial Homeostasis and Inflammation.Molecules (Basel, Switzerland) · 2026Article
- Characterization ofPlants (Basel, Switzerland) · 2026Article
- Phytochemical Characterization ofFood science & nutrition · 2026Article
- Tyrosinase Inhibitors With Enhanced Potency in Mammalian and Vertebrate Models, N-(2-Mercaptoethyl)benzamide Derivatives: Design, Synthesis, and Evaluation.Chemical biology & drug design · 2026Article
- Antimicrobial and Antityrosinase Activity of Bakuchi Oil-Chitosan Hydrogel With In Silico Insights.Chemistry & biodiversity · 2026Article
287 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.