ArticleJournal of enzyme inhibition and medicinal chemistry2019
Identification and characterization of the α-CA in the outer membrane vesicles produced by Helicobacter pylori.
Article in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
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- Outer membrane vesicles in gram-negative bacteria and its correlation with pathogenesis.Frontiers in immunology · 2025Review
- Proteomic Analysis of the Fish PathogenAnimals : an open access journal from MDPI · 2024Article
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- Latest Update on Outer Membrane Vesicles and Their Role in Horizontal Gene Transfer: A Mini-Review.Membranes · 2023Review
- Antimicrobial and Antibiofilm Activities of Carvacrol, Amoxicillin and Salicylhydroxamic Acid Alone and in Combination vs.International journal of molecular sciences · 2023Article
- Carbonic Anhydrase Inhibitors as Novel Antibacterials in the Era of Antibiotic Resistance: Where Are We Now?Antibiotics (Basel, Switzerland) · 2023Review
- The gram-negative bacteriumJournal of enzyme inhibition and medicinal chemistry · 2022Article
- May Sulfonamide Inhibitors of Carbonic Anhydrases fromInternational journal of molecular sciences · 2022Article
- In Vitro Activity of the Arylaminoartemisinin GC012 againstPathogens (Basel, Switzerland) · 2022Article
- Current and future perspectives forFrontiers in cellular and infection microbiology · 2022Review
- Selective Inhibition ofInternational journal of molecular sciences · 2021Article
- Enhanced Antibacterial Potential of Amoxicillin againstAntibiotics (Basel, Switzerland) · 2021Article
- Synthesis and Evaluation of Thymol-Based Synthetic Derivatives as Dual-Action Inhibitors against Different Strains ofMolecules (Basel, Switzerland) · 2021Article
- Effect of Sulfonamides and Their Structurally Related Derivatives on the Activity of ι-Carbonic Anhydrase fromInternational journal of molecular sciences · 2021Article
- Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition inFrontiers in microbiology · 2021Review
- Outer Membrane Vesicles Derived fromMicroorganisms · 2020Article
- Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genome of Helicobacter pylori encodes for carbonic anhydrases (CAs, EC 4.2.1.1) belonging to the α- and β-CA classes, which together with urease, have a pivotal role in the acid acclimation of the microorganism within the human stomach. Recently, in the exoproteome of H. pylori, a CA with no indication of the corresponding class was identified. Here, using the protonography and the mass spectrometry, a CA belonging to the α-class was detected in the outer membrane vesicles (OMVs) generated by planktonic and biofilm phenotypes of four H. pylori strains. The amount of this metalloenzyme was higher in the planktonic OMVs (pOMVs) than in the biofilm OMVs (bOMVs). Furthermore, the content of α-CA increases over time in the pOMVs. The identification of the α-CA in pOMVs and bOMVs might shed new light on the role of this enzyme in the colonization, survival, persistence, and pathogenesis of H. pylori.
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