ArticleJournal of enzyme inhibition and medicinal chemistry2019
Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties.
Article in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Beyond Urease: New Potential Enzymatic Targets inACS omega · 2026Review
- The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases.Archiv der Pharmazie · 2025Review
- Recent Advances in Design, Synthesis, and Biological Activity Studies of 1,3-Selenazoles.Biomolecules · 2024Review
- A cheminformatics and network pharmacology approach to elucidate the mechanism of action ofFrontiers in pharmacology · 2024Article
- Antimicrobial and Antibiofilm Activities of Carvacrol, Amoxicillin and Salicylhydroxamic Acid Alone and in Combination vs.International journal of molecular sciences · 2023Article
- Biological investigation ofJournal of enzyme inhibition and medicinal chemistry · 2022Article
- Article
- Selective Inhibition ofInternational journal of molecular sciences · 2021Article
- In Silico-Guided Identification of New Potent Inhibitors of Carbonic Anhydrases Expressed inACS medicinal chemistry letters · 2020Article
- Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase fromInternational journal of molecular sciences · 2020Article
- Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of benzenesulfonamides incorporating selenazoles with diverse substitution patterns were investigated as inhibitors of six bacterial carbonic anhydrases (CAs, EC 4.2.1.1) from bacterial pathogens, such as Helicobacter pylori (hpCAα was the investigated enzyme), Vibrio cholerae (all the three CAs from this pathogen were considered, VchCAα, VchCAβ and VchCAγ) and Burkholderia pseudomallei (with its two CAs, BpsCAβ and BpsCAγ). All these sulfonamides were effective CA inhibitors, with potencies in the low micromolar or submicromolar range, making them attractive as lead compounds for designing antibacterials with a novel mechanism of action, which could counteract the extensive resistance problem observed with many clinically used antibiotics.
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Registered trials
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