Evidence map›Paper›PMID 30734490›Full record

ArticleThoracic cancer2019

Clinicopathological characteristics and prognostic factors of pulmonary large cell neuroendocrine carcinoma: A large population-based analysis.

Qiao Yang, Zihan Xu, Xiewan Chen, Linpeng Zheng, Yongxin Yu, Xianlan Zhao, Mingjing Chen, Bangyu Luo, Jianmin Wang, Jianguo Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qiao YangCancer Institute of People's Liberation Army, Xinqiao Hospital, Army Medical University, Chongqing, China.
Zihan XuCancer Institute of People's Liberation Army, Xinqiao Hospital, Army Medical University, Chongqing, China.ORCID 0000-0001-5499-4803
Xiewan ChenMedical English Department, College of Basic Medicine, Army Medical University, Chongqing, China.
Linpeng ZhengCancer Institute of People's Liberation Army, Xinqiao Hospital, Army Medical University, Chongqing, China.
Yongxin YuCancer Institute of People's Liberation Army, Xinqiao Hospital, Army Medical University, Chongqing, China.
Xianlan ZhaoCancer Institute of People's Liberation Army, Xinqiao Hospital, Army Medical University, Chongqing, China.
Mingjing ChenCancer Institute of People's Liberation Army, Xinqiao Hospital, Army Medical University, Chongqing, China.
Bangyu LuoCancer Institute of People's Liberation Army, Xinqiao Hospital, Army Medical University, Chongqing, China.
Jianmin WangCancer Institute of People's Liberation Army, Xinqiao Hospital, Army Medical University, Chongqing, China.
Jianguo SunCancer Institute of People's Liberation Army, Xinqiao Hospital, Army Medical University, Chongqing, China.ORCID 0000-0001-5214-6413
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study was conducted to compare the clinicopathological characteristics, survival outcomes, and metastatic patterns between pulmonary large cell neuroendocrine carcinoma (LCNEC) and other non-small cell lung cancer (ONSCLC), and to identify the prognostic factors of LCNEC.

methodsData of patients diagnosed with LCNEC and ONSCLC from 2004 to 2014 were obtained from the Surveillance, Epidemiology, and End Results dataset. Pearson's chi-square tests were used to compare differences in clinicopathological characteristics. The Kaplan-Meier method was used for survival analysis. A propensity score was used for matching and a Cox proportional hazards model was used for multivariate and subgroup analyses.

resultsA total of 2368 LCNEC cases and 231 672 ONSCLC cases were identified. LCNEC incidence increased slightly over time. Except for marital status, LCNEC patients had obviously different biological features to ONSCLC patients. Survival analysis showed that LCNEC had poorer outcomes than ONSCLC. Multivariate analysis revealed that female gender, black race, surgery, radiation, and chemotherapy were protective factors for LCNEC. Matched subgroup analysis further demonstrated that most subgroup factors favored ONSCLC, especially in early stage. Early-stage LCNEC patients had a higher risk of lung cancer-specific death than early-stage ONSCLC patients. Moreover, metastatic patterns were different between LCNEC and ONSCLC. LCNEC patients with isolated liver metastasis or combined invasion to other organs had poorer survival rates.

conclusionsLCNEC has totally different clinicopathological characteristics and metastatic patterns to ONSCLC. LCNEC also has poorer survival outcomes, primarily because of isolated liver metastasis or combined invasion to other organs. Most subgroup factors are adverse factors for LCNEC.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Large CellCarcinoma, NeuroendocrineCarcinoma, Non-Small-Cell LungFemaleHumansLung NeoplasmsMaleMiddle AgedMultivariate AnalysisPrognosisPropensity ScoreSEER ProgramSurvival AnalysisClinicopathological characteristicmetastasisprognostic factorpulmonary large cell neuroendocrine carcinomaSEER

Identifiers

PMID30734490
PMCPMC6449250
OpenAlexW2911629185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.