ReviewJournal of cellular and molecular medicine2019
Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment.
Review in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05732064 (Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients), which is not on this map. Cited by 573 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial
Who cites it
573 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,089 citations in OpenAlex.
- Effects of Agomelatine on Sleep Across Populations: A Systematic Review and Meta-Analysis.Journal of sleep research · 2026Pooled it
- Efficacy of auriculotherapies for primary insomnia: A systematic review and network meta-analysis.Medicine · 2026Pooled it
- Long-term neurological and cognitive impact of COVID-19: a systematic review and meta-analysis in over 4 million patients.BMC neurology · 2025Pooled it
- Efficacy and safety of each class of sleep medication for major depressive disorder with insomnia symptoms: A systematic review and meta-analysis of double-blind randomized controlled trials.Psychiatry and clinical neurosciences · 2025Pooled it
- Meta-Analysis of the Clinical Efficacy of Auricular Acupressure on Patients with Depression.Alpha psychiatry · 2025Pooled it
- Pooled it
- Global trends and hotspots in exercise therapy for insomnia research: bibliometric and visual analysis.Frontiers in neurology · 2025Pooled it
- Neural mechanism of Shugan Jieyu combined with zolpidem in insomnia disorder with depressive symptoms: evidence from event-related potentials in Go/No-Go and psychomotor vigilance task.BMC psychiatry · 2026Trial
- Bilateral transcutaneous auricular vagus nerve stimulation for the treatment of insomnia in breast cancer.Scientific reports · 2025Trial
- Effects of remotely-delivered cognitive behavioral therapy for insomnia in type 2 diabetes: a randomized controlled trial.Sleep & breathing = Schlaf & Atmung · 2025Trial
- Efficacy and safety of Shugan Jieyu capsules in combination with zolpidem for insomnia disorder with depressive symptoms: a double-blind randomized controlled trial.BMC complementary medicine and therapies · 2025Trial
- Exploring Factors Associated with Sleep Quality After Lung Transplantation.Progress in transplantation (Aliso Viejo, Calif.) · 2025Trial
- Efficacy and safety of lemborexant in subjects with insomnia disorder receiving medications for depression or anxiety symptoms.Neuropsychopharmacology reports · 2025Trial
- Remote Longitudinal Tracking of Sleep, Depression, and Cognition Across Early Adolescence: Protocol for a Longitudinal Observational Study.JMIR research protocols · 2026Article
- Sleep disturbances as early indicators of incident psychiatric disease.European archives of psychiatry and clinical neuroscience · 2026Article
- Burden of Insomnia Among Individuals With Major Depressive Disorder: Cross-Sectional Observational Study.Interactive journal of medical research · 2026Article
- Association of Vitamin D and B12 Levels with Actigraphic Sleep in Cognitively Unimpaired Middle-Aged and Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Circadian Syndrome and Stress Urinary Incontinence in Adult American Women: A NHANES Cross-Sectional Study.Urology research & practice · 2026Article
- Increased prevalence of depressive symptoms and stress in patients with chronic bothersome tinnitus during the COVID-19 pandemic.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Symptom Clusters and Frailty Among Older Adults With and Without Cancer: Insights From Two Cross-Sectional Studies.Nursing & health sciences · 2026Article
513 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among young, middle-aged and older adults. This bidirectional association between sleep disturbance and depression has created a new perspective that sleep problems are no longer an epiphenomenon of depression but a predictive prodromal symptom. In this review, we highlight the treatment of sleep disturbance before, during and after depression, which probably plays an important role in improving outcomes and preventing the recurrence of depression. In clinical practice, pharmacological therapies, including hypnotics and antidepressants, and non-pharmacological therapies are typically applied. A better understanding of the pathophysiological mechanisms between sleep disturbance and depression can help psychiatrists better manage this comorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.