ArticleAddiction biology2020
N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking.
Article in Addiction biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review.Pharmacological reviews · 2022Pooled it
- Evaluating N-acetylcysteine for early and end-of-treatment abstinence in adult cigarette smokers.Drug and alcohol dependence · 2021Trial
- An evaluation of N-acetylcysteine in a sequential oxycodone and cocaine rat self-administration model.Experimental and clinical psychopharmacology · 2026Article
- A single extinction-based treatment with N-Acetylcysteine produces long-term reduction in cocaine relapse.Translational psychiatry · 2026Article
- Selective Effects of Acutely Administered N-Acetyl-Cysteine in Rodent Models of Nicotine-Conditioned Behaviours.Addiction biology · 2025Article
- The role of glucocorticoid and nicotinic acetylcholine receptors in the reward-enhancing effects of nicotine in the ICSS procedure in male and female rats.Drug and alcohol dependence · 2025Article
- Fluorocitrate inhibition of astrocytes reduces nicotine self-administration and alters extracellular levels of glutamate and dopamine within the nucleus accumbens in male wistar rats.Neuropharmacology · 2024Article
- Chronic N-acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy.Experimental physiology · 2024Article
- The importance of translationally evaluating steroid hormone contributions to substance use.Frontiers in neuroendocrinology · 2023Review
- Logical fallacies and misinterpretations that hinder progress in translational addiction neuroscience.Journal of the experimental analysis of behavior · 2022Article
- Natural and synthetic estrogens specifically alter nicotine demand and cue-induced nicotine seeking in female rats.Neuropharmacology · 2021Article
- N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research.Pharmacological reports : PR · 2021Review
- Strain and sex matters: Differences in nicotine self-administration between outbred and recombinase-driver transgenic rat lines.Experimental and clinical psychopharmacology · 2021Article
- Nicotine formulations impact reinforcement-related behaviors in a mouse model of vapor self-administration.Drug and alcohol dependence · 2021Article
- A Gender Perspective of Addictive Disorders.Current addiction reports · 2021Review
- Direct administration of ifenprodil and citalopram into the nucleus accumbens inhibits cue-induced nicotine seeking and associated glutamatergic plasticity.Brain structure & function · 2020Article
- Review
- Sex differences in the glutamate system: Implications for addiction.Neuroscience and biobehavioral reviews · 2020Review
- Administration ofFrontiers in behavioral neuroscience · 2020Article
- Economic demand analysis of within-session dose-reduction during nicotine self-administration.Drug and alcohol dependence · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Women report greater craving during certain phases of the menstrual cycle. As well, research indicates that pharmacotherapies for smoking may be less efficacious in women compared with men, which may be due to interactions with natural fluctuations in ovarian hormone levels. N-Acetylcysteine (NAC) is a glutamatergic compound that has shown some efficacy in treating substance use disorders and aids in the prevention of relapse. However, it is unclear whether NAC has sex-specific effectiveness for nicotine relapse treatment. Given that NAC has shown promise to reduce nicotine reinstatement in preclinical models using male rats, the exploration of potential sex differences in the efficacy of NAC is warranted. Using a rat model, we first investigated the ability of NAC treatment (100 mg/kg, ip) during nicotine withdrawal with extinction training to reduce cue-induced nicotine seeking in male and female rats. Next, we assessed whether NAC's effects were estrous cycle-dependent for female rats. Results show that following NAC treatment during extinction, reinstatement of nicotine seeking was significantly decreased in males but not females, indicating a sex-specific effect of NAC. Furthermore, for females, both vehicle- and NAC-treated groups significantly reinstated nicotine-seeking behavior compared with extinction, regardless of estrous cycle phase. These results suggest that NAC is inefficacious in reducing nicotine relapse in females regardless of estrous cycle phase at the dose evaluated here. These collective findings could have important clinical implications for use and efficacy of NAC as a pharmacotherapy for freely cycling women smokers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.