Evidence map›Paper›PMID 30734230›Full record

Observational studyObesity surgery2019

Impact of Bariatric Surgery on Bone Mineral Density: Observational Study of 110 Patients Followed up in a Specialized Center for the Treatment of Obesity in France.

Marion Geoffroy, Isabelle Charlot-Lambrecht, Jan Chrusciel, Isabelle Gaubil-Kaladjian, Ana Diaz-Cives, Jean-Paul Eschard, Jean-Hugues Salmon

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04174495 (Bone Fragility Evaluation by Dual X-Ray Absorptiometry), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04174495 completednot on this mapstarted 2020, after this paper: background citation

Bone Fragility Evaluation by Dual X-Ray Absorptiometry (DXA) and CT-scan (vertebral Fracture and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra SBAC-L1) in Obese Patients

TypeobservationalSponsorCentral Hospital, Nancy, FranceRan2020 to 2021Enrolled1,500ConditionsObesity, Bariatric Surgery CandidateArmsDXA and CT-scan
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. The change of bone mineral density and bone metabolism after gastrectomy for gastric cancer: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Marion GeoffroyCHU Reims, Service de Rhumatologie, Hôpital Maison Blanche, F-51092, Reims, France. mgeoffroy@chu-reims.fr.ORCID 0000-0001-8774-7104
Isabelle Charlot-LambrechtCHU Reims, Service de Rhumatologie, Hôpital Maison Blanche, F-51092, Reims, France.
Jan ChruscielCHU Reims, Service de Recherche Clinique, Hôpital Robert Debré, F-51092, Reims, France.
Isabelle Gaubil-KaladjianCHU Reims, Service d'Endocrinologie et nutrition, Hôpital Robert Debré, F-51092, Reims, France.
Ana Diaz-CivesCHU Reims, Service de chirurgie digestive, Hôpital Robert Debré, F-51092, Reims, France.
Jean-Paul EschardCHU Reims, Service de Rhumatologie, Hôpital Maison Blanche, F-51092, Reims, France.
Jean-Hugues SalmonCHU Reims, Service de Rhumatologie, Hôpital Maison Blanche, F-51092, Reims, France.
Centre Hospitalier Universitaire de Reims · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBariatric surgery is used to treat severe obesity. We aimed to investigate the incidence of clinically significant bone mineral density (BMD) loss at 6 and 12 months after bariatric surgery.

methodsObservational study performed in a specialized center for the treatment of obesity at the University Hospital of Reims, France. Surface BMD was measured by dual x-ray absorptiometry (DEXA). A reduction of > 0.03 g/cm

resultsA total of 110 patients were included. A clinically significant reduction in BMD was observed in 62.1% of patients at 6 months, and in 71.6% at 12 months after surgery. No case of osteoporosis was observed. There were four cases of osteopenia and one fracture post-surgery. BMD loss was related by univariate analysis to the reduction in body mass index (BMI) (p < 0.01), weight loss (p < 0.01), fat mass (p < 0.01), and lean mass (p < 0.01). Multivariable analysis found a significant association between the reduction in BMD and the excess weight loss percentage (odds ratio 1.11, 95% confidence interval (1.05-1.18), p < 0.001).

conclusionThere was a clinically significant reduction in BMD at 6 months after surgery in over 60% of patients undergoing bariatric surgery. BMD loss is persistent over time and predominantly situated at the femoral level, and strongly associated with weight loss. Systematic vitamin and calcium supplementation, as well as follow-up by DEXA scan seems appropriate. Systematic DEXA scan pre- and post-surgery, and annually thereafter until weight has stabilized seems appropriate.

Indexed as

Absorptiometry, PhotonAdultBariatric SurgeryBody Mass IndexBone Diseases, MetabolicFemaleFranceHumansIncidenceMaleMiddle AgedObesity, MorbidPostoperative ComplicationsTime FactorsWeight LossBariatric surgeryBone densitometryBone mineral densityFracture, obesity

Identifiers

PMID30734230
OpenAlexW2911881741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.