Evidence map›Paper›PMID 30734227›Full record

SynthesisMolecular neurobiology2019

Systematic Review of miRNA as Biomarkers in Alzheimer's Disease.

S Swarbrick, N Wragg, S Ghosh, Alexandra Stolzing

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  18. miR-584-5p suppresses AβActa neurologica Belgica · 2026
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  20. Article

146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

S SwarbrickCentre for Biological Engineering, Wolfscon School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
N WraggCentre for Biological Engineering, Wolfscon School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
S GhoshCentre for Biological Engineering, Wolfscon School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
Alexandra StolzingCentre for Biological Engineering, Wolfscon School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK. A.Stolzing@lboro.ac.uk.ORCID http://orcid.org/0000-0002-2975-5736

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a progressive decline in cognitive impairment. Small non-coding microRNA (miRNA) sequences have been found to be deregulated in the peripheral blood of Alzheimer patients. A systematic review was conducted to extract all miRNA found to be significantly deregulated in the peripheral blood. These deregulated miRNAs were cross-referenced against the miRNAs deregulated in the brain at Braak Stage III. This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. After network analysis of the 10 miRNAs, they were found to be associated with the immune system, cell cycle, gene expression, cellular response to stress, neuron growth factor signalling, wnt signalling, cellular senescence, and Rho GTPases.

Indexed as

Alzheimer DiseaseAnimalsBiomarkersBrainGene Regulatory NetworksHumansMicroRNAsBiomarkersMicroRNAsAlzheimer diseaseBiomarkersBrainmiRNAPeripheral blood

Identifiers

PMID30734227
PMCPMC6682547

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.