Evidence map›Paper›PMID 30734226›Full record

ArticleMolecular neurobiology2019

Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases.

Guendalina Olivero, Matteo Vergassola, Francesca Cisani, Cesare Usai, Anna Pittaluga

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  4. Article
  5. Review
  6. Review
  7. Antibodies Against the NHFrontiers in immunology · 2021
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Guendalina OliveroDepartment of Pharmacy, DiFAR, Pharmacology and Toxicology Section, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy.
Matteo VergassolaDepartment of Pharmacy, DiFAR, Pharmacology and Toxicology Section, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy.
Francesca CisaniDepartment of Pharmacy, DiFAR, Pharmacology and Toxicology Section, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy.
Cesare UsaiInstitute of Biophysics, National Research Council, via De Marini 6, 16149, Genoa, Italy.
Anna PittalugaDepartment of Pharmacy, DiFAR, Pharmacology and Toxicology Section, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy. pittalug@difar.unige.it.ORCID http://orcid.org/0000-0002-4011-1165
University of Genoa · ITNational Research Council · ITOspedale Policlinico San Martino · IT

Funding

Università degli Studi di Genova not available
6 · The paper itself

Abstract

Mouse hippocampal glutamatergic nerve endings express presynaptic release-regulating NMDA autoreceptors (NMDARs). The presence of GluN1, GluN2A, GluN2B, and GluN3A subunits in hippocampal vesicular glutamate transporter type 1-positive synaptosomes was confirmed with confocal microscopy. GluN2C, GluN2D, and GluN3B immunopositivity was scarcely present. Incubation of synaptosomes with the anti-GluN1, the anti-GluN2A, the anti-GluN2B, or the anti-GluN3A antibody prevented the 30 μM NMDA/1 μM glycine-evoked [

Indexed as

AnimalsAntibodiesAspartic AcidAutoimmune DiseasesGlutamic AcidHippocampusHydrogen-Ion ConcentrationMice, Inbred C57BLPotassium ChloridePresynaptic TerminalsProtein SubunitsReceptors, N-Methyl-D-AspartateSynaptosomesTritiumAntibodiesAspartic AcidGluN3A protein, mouseGlutamic AcidPotassium ChlorideProtein SubunitsReceptors, N-Methyl-D-AspartateTritiumAnti-GluN antibodyComplementGluN3NMDA internalizationPresynaptic NMDA autoreceptor

Identifiers

PMID30734226
OpenAlexW2915058714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.