ArticleClinical and experimental nephrology2019
The impact of the combination of kidney and physical function on cognitive decline over 2 years in older adults with pre-dialysis chronic kidney disease.
Article in Clinical and experimental nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Cognitive Impairment and Brain Atrophy in Patients with Chronic Kidney Disease.Journal of clinical medicine · 2024Review
- Current Status of the Cognitive Impairment in Chronic Kidney Disease.Physical therapy research · 2024Review
- Current status of the assessment of sarcopenia, frailty, physical performance and functional status in chronic kidney disease patients.Current opinion in nephrology and hypertension · 2022Review
- Relationship between serum inorganic phosphorus levels and cognitive decline over 2 years in older adults with pre-dialysis chronic kidney disease.Clinical and experimental nephrology · 2020Article
- Physical function, functional capacity, cognition, and brain structure and function in older adults with chronic kidney disease (CKD).Geriatric nursing (New York, N.Y.)Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundNo longitudinal study has investigated the impact of combination of kidney function (KF) and physical function (PF) on cognitive decline in these patients.
methodsWe conducted a 2-year prospective cohort study enrolling 131 patients ≥ 65 years with pre-dialysis chronic kidney disease (CKD). We assessed cognitive function with the Japanese version of the Montreal Cognitive Assessment (MoCA-J). We calculated %MoCA-J based on the rate of change between baseline and follow-up MoCA-J scores, and defined cognitive decline over 2 years as a %MoCA-J of less than the first quartile value. We defined eGFR ≥ 30 as mild-to-moderate and eGFR < 30 mL/min per 1.73 m
resultsEighty-four patients completed follow-up assessment. Multivariate logistic regression analysis showed that the combination of severe impairment in KF and low PF was significantly associated with cognitive decline (odds ratio 5.73). However, no significant cognitive decline was observed in patients with either severe impairment in KF or low PF alone.
conclusionsWe may need to focus on maintaining PF in older patients with advanced CKD may help to prevent cognitive decline.
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